Entry information : MtuCP01_H37rv
Entry ID 3551
Creation 2006-08-24 (Filippo Passardi)
Last sequence changes 2006-08-24 (Filippo Passardi)
Sequence status complete
Reviewer Christophe Dunand
Last annotation changes 2006-08-24 (Christophe Dunand)
Peroxidase information: MtuCP01_H37rv
Name MtuCP01_H37rv
Class Catalase peroxidase    [Orthogroup: CP001]
Taxonomy Bacteria Actinobacteria Actinobacteria (class) Mycobacteriaceae Mycobacterium
Organism Mycobacterium tuberculosis    [TaxId: 1773 ]
Cellular localisation N/D
Tissue type N/D
Inducer N/D
Repressor N/D
Best BLASTp hits
Perox score E-value MtuCP01_H37rv
start..stop
S start..stop
MtuCP01_G6108 1512 0 1..740 1..740
MtuCP01_Rm33 1511 0 1..740 1..740
MtuCP01_Rm29 1511 0 1..740 1..740
MtuCP01_Rm08 1511 0 1..740 1..740
Literature and cross-references MtuCP01_H37rv
Literature [1]
Heym B., Zhang Y., Poulet S., Young D., Cole S.T.;
"Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.";
J. Bacteriol. 175:4255-4259(1993).

[2]
Cockerill F.R., Uhl J.R., Temesgen Z., Zhang Y., Stockman L., Roberts G.D., Williams D.L., Kline B.C.;
"Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.";
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.

[3]
Marttila H.J., Soini H., Huovinen P., Viljanen M.K.;
"katG gene mutations in isoniazid-resistant Mycobacterium tuberculosis strains isolated from Finnish patients.";
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.

[4]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).

[5]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).

[6]
Zhang Y., Heym B., Allen B., Young D., Cole S.T.;
"The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.";
Nature 358:591-593(1992).

[7]
Song J., Deretic V.;
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Protein ref. UniProtKB:   Q08129
DNA ref. GenBank:   581367
Protein sequence: MtuCP01_H37rv
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   740
PWM (Da):   %s   80398.16  
PI (pH):   %s   4.83
Sequence
Send to BLAST
Send to Peroxiscan
.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2
MPEQHPPITE TTTGAASNGC PVVGHMKYPV EGGGNQDWWP NRLNLKVLHQ NPAVADPMGA AFDYAAEVAT IDVDALTRDI EEVMTTSQPW WPADYGHYGP LFIRMAWHAA GTYRIHDGRG  GAGGGMQRFA PLNSWPDNAS LDKARRLLWP VKKKYGKKLS WADLIVFAGN CALESMGFKT FGFGFGRVDQ WEPDEVYWGK EATWLGDERY SGKRDLENPL AAVQMGLIYV NPEGPNGNPD  PMAAAVDIRE TFRRMAMNDV ETAALIVGGH TFGKTHGAGP ADLVGPEPEA APLEQMGLGW KSSYGTGTGK DAITSGIEVV WTNTPTKWDN SFLEILYGYE WELTKSPAGA WQYTAKDGAG  AGTIPDPFGG PGRSPTMLAT DLSLRVDPIY ERITRRWLEH PEELADEFAK AWYKLIHRDM GPVARYLGPL VPKQTLLWQD PVPAVSHDLV GEAEIASLKS QIRASGLTVS QLVSTAWAAA  SSFRGSDKRG GANGGRIRLQ PQVGWEVNDP DGDLRKVIRT LEEIQESFNS AAPGNIKVSF ADLVVLGGCA AIEKAAKAAG HNITVPFTPG RTDASQEQTD VESFAVLEPK ADGFRNYLGK  GNPLPAEYML LDKANLLTLS APEMTVLVGG LRVLGANYKR LPLGVFTEAS ESLTNDFFVN LLDMGITWEP SPADDGTYQG KDGSGKVKWT GSRVDLVFGS NSELRALVEV YGADDAQPKF 
VQDFVAAWDK VMNLDRFDVR 

Retrieve as FASTA  
Remarks Identical sequence in strains ATCC 25618, CDC1551, 15726/89, H0251/90, H0359/91, H0055/92, H0452/92, H0892/92, H0948/92, H0004/93, H0169/93, H0181/94, H0725/93, H0211/94 and L33308 (NCBI AAA18239, SwissProt Q50482) WARNING! Identical sequence probably also in strain CNFD04032 if we assume that there was a sequencing error (lack of one cytidine: see MtuCP01_CNFD04032).