Entry information : HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)
Entry ID 3600
Creation 2007-01-25 (Filippo Passardi)
Last sequence changes 2016-06-28 (Harold Duruflé)
Sequence status complete
Reviewer Not yet reviewed
Last annotation changes 2016-06-28 (Harold Duruflé)
Peroxidase information: HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)
Name (synonym) HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)
Class Animal glutathione peroxidase    [Orthogroup: Gpx1003]
Taxonomy Eukaryota Metazoa Chordata Mammalia Hominidae Homo
Organism Homo sapiens (human)    [TaxId: 9606 ]
Cellular localisation Cytosolic
Tissue type N/D
Inducer Constitutively induced
Repressor N/D
Best BLASTp hits
Perox score E-value HsGPx01-A
start..stop
S start..stop
PtroGPx01-A 390 4e-141 14..203 12..201
PpyGPx01 389 2e-140 14..203 12..201
HlGPx01 388 3e-140 14..203 12..201
MfGPx01 384 2e-138 14..203 12..201
Gene structure Fichier Exons
ExonStart..EndSize ExonStart..EndSize ExonStart..EndSize ExonStart..EndSize
N° 1 1..252 252 N° 2 532..891 360  
join(1..252,532..891)


exon

Literature and cross-references HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)
Literature REFERENCE 1 Sukenaga Y., Ishida K., Takeda T., Takagi K. cDNA sequence coding for human glutathione peroxidase. Nucleic Acids Res. 15:7178-7178(1987).

REFERENCE 2 Ishida K., Morino T., Takagi K., Sukenaga Y. Nucleotide sequence of a human gene for glutathione peroxidase.
Nucleic Acids Res. 15:10051-10051(1987).

REFERENCE 3 Mullenbach G.T., Tabrizi A., Irvine B.D., Bell G.I., Hallewell R.A. Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine. Nucleic Acids Res. 15:5484-5484(1987).

REFERENCE 4 Chada S., le Beau M.M., Casey L., Newburger P.E. Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics 6:268-271(1990).
Protein ref. UniProtKB:   P07203   Q6NSD4 [Fragment]
DNA ref. GenBank:   NC_000003.11 (49395711..49394824)
Cluster/Prediction ref. Genebank:   2876 UniGene:   Hs.76686
Protein sequence: HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   203
PWM (Da):   %s   21853.12  
PI (pH):   %s   6.52
Sequence
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.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASL*GTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA*

Retrieve as FASTA  
Remarks Complete sequence from 1079 ESTs, 19 cDNA and DNA (chromo 3, 1 intron).Two transcript variants HsGPx01-a and HsGPx01-b cumulated. Q6NSD4 (first 57 aa are missing: fragment or splicing variant?).
Promoter
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.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
GGCGCCCCTC CTACCCCGGC TGCTTGGCAG TTGCAGTGCT GCTGTCTCGG GGGGGTTTTC ATCTATGAGG GTGTTTCCTC TAAACCTACG AGGGAGGAAC ACCTGATCTT ACAGAAAATA  CCACCTCGAG ATGGGTGCTG GTCCTGTTGA TCCCAGTCTC TGCCAGACCA AGGCGAGTTT CCCCACTAAT AAAGTGCCGG GTGTCAGCAG AACTGTGTGT ATGTCCTGTG TCATTGTCAT  TTGGGAATTC TTTTTCTTTT CTTTTTTTTT TTTTTTTTTT GAGACGGAGT TTTTTGCTCT ATTGCCCAGG CTGGAGTGCA GTGGCGCAAT CTAGGCTCAC TGCAAGCTCC GCCTCCCGGG  TTCACGCCAT TCTCCTGCCT CAACCTCCTG AGTAGCTGGG ACTACAGGTG CCTGCCACCA CGCCCGGCTA ATTTTTTGTA TTTTTAGTAG AGACAGGGTT TCACCGTGTT AGCCAGGATG  GTATCGATCT CCTGACCTCG TGATCCACCC GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTATGAGCC ACCGCACCCG GCCTGGCGAT ACTTTTTCTA ACCTCATTGT CATAGTGGTG  GGAACTTAAT CCTCCTTCCC TTATCCTAGC CAAGTCTGAA CTTTCTGTCC TTTTGTCTGC AGCGTGTAGG ATCCACTCTT TCCTTTGTGG GAAGTCTGGC TCCTGGCCTG CATTTCTGCC  TTCACCAGAA CATGCAAAGG GCCATCTCAA GACCCAGTTA CAACAAAGTC CTTACTTCAA AAAAGACACA AGGCAATGGT TGACTGCCTA ACTCAAATGA TAGACTTCTG ACTACTTGCT  GCACGCTGAA ATGACTGTCA CAAAATAACA TGAGCCCCCA CTCACATTTG GAGTCATGGC CTCTCCAATT GTTAGGTCCA CACAATCCCA TTTTACACGG AAGCTCATGC AATGTTATAA  ATTCTGTTAT CTGGCTAGAT CTTTCCATGT TGCTACCAAG TGCCTGTATC TGCTGTGACG ATGATCTTAC AAGTTTCTGC CTCATATATT CAAGAGTGAG AAAACTATAA TTTAACTGGC  CCTTCTGACT ATGCCCTGCC CAACACTTAA CGTGCAATTA ATTGCACATT CAGGCCCAGG ATAAGGGCTT GTCTTTGAAG CCAGCTGCTG CTTCTCGGGC ACCACTCAGG TCCAGCCTCT  CCATCTGTTG ACCCTGCTGC CAATAATCTT TAATTTTTTT TTTTTTTTTT TTTTTTTTGA GACAGTCTTG CTCTGTTGCG CAGGCTGGAG TGCAGTGGTG TAATCTCGGC TCACTGCAAG  CTCCGCCTCC CGGGTTCACG CCATTCTGCC TCAGCCTCCC GAGTAGCTGG GACTACAGGC GCCCGCCACC ACGCCCGGCT AATTTTTTTC TGTTTTTTAG TAGACGGGGT TTCACCGTGT  TAGCCAGGAT GGTCTCGATC TCCTGACCTC GTGATCCACC CGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCTTGAGC AGCAATAATC TTTCAAGACA GATTTGGAGC CATTTCCTAA  CGCAGTGCAG GGGACTGCAG GGCCTGGGTG TAGCTTCCGC TTGTGCAAAC AGGTACCCAG AGACATGGTA GTGCTGTTCA CCCGCTGACT GTGGACCAGA GGTTCTGGAG TCCCAGCATT  TGTGTTCAAA TTCGTGACTC AAGGTCCTTC TTAGTCTGAA CCAACTCTCA AGGACTTTTC CTCTTGCCCT AAGCAGTGAT CTTTGCTGCT GCTTTCCCCC TTTGTCTGCC CTTAGGTCAC  TAAGGATTGT AGGGCCTTCT GGACCTGCTC TGGCTCCATC CTGAGAACTC CTGAACAGGC CCACCTCCCT CTGGTTCTCT CTGCCCCAGC CTTTGAGTCC CCCTTGGGGT GACCCAGGTA 
GAACTATCAG CTTCCCCTTT GGACCTCACT CTACTTGTGT TGTTCCTTGG AACTCTCAGG AGTCTCACTC TTGCCCAGGC 

Retrieve as FASTA  
Terminator +
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Send to cis Analysis
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATCCAGGTTC CCTCCCAGAG GAGCCACCAG TTCTCATGGG TGGCACTCAG TCTCTCTTCT CTCCAGCTGA CTAAACTTTT TTTCTGTACC AGTTAATTTT TCCAACTACT AATAGAATAA  AGGCAGTTTT CTAAACTTCC TGTATCCTGT TGTTTGTGTT GCTCTCTCCA GGGCTGGGGG TAGGAGGATG CAAGGACTTC CTGGCCTAGC TCACCCTGGA GAGGTTTGTT GAGTGCAAAG  GACTAGCTTG TGCCCCACCT CCCACCCACC CAGCAGCTAA TCTGGTCCCT CCCAACAACA TGGAAATGAT TACCCTGTAC CGCATTCTGG TTCAGATTTG GGGGTAGGGT GAATGCAGCC  TGAGGAGGCC AGGGAGGGAG GACTCCGGCA GCGTTTCCTT GGCCTCGGCG AGCTACTGGG CTCCACTTAA GGAGGCTGGG GCAGAGCTTC CAGGACTCTG CCCGGTTAGA AAACCCGCAC  GAGGGCGGTG CCGCTTTGGA GACAGGGAGG AGGGAGACCG GAAGCCTAGA TCCCTCTGGC TGTCCCCTGC ACTGCCGGTA ACATGGCACA GGAGAGGAGG GCTGTTTGTG CACGGGCAGC  TCCTGCAGCT GCTGCCGTCG CCCACCAGCC TCCTATGCCA AACCCCACAT CCTAACTCAG GAACCTCTGA GAAAAAACGG AGCCCTCGAG GGCCCCAGCC CTTGGAAGGG TAACCTGGAC  CGCTGCCGCC TGGTTGCCTG GGCCAGACCA GACATGCCTG CTGCTCCTTC CGGCTTAGGA GGAGCACGCG TCCCGCTCGG GCGCACTCTC CAGCCTTTTC CTGGCTGAGG AGGGGCCGAG  CCCTCCGGGT AGGGCGGGGG CCGGATGAGG CGGGACCCTC AGGCCCGGAA AACTGCCTGT GCCACGTGAC CCGCCGCCGG CCAGTTAAAA GGAGGCGCCT GCTGGCCTCC CCTTACAGTG 
CTTGTTCGGG GCGCTCCGCT GGCTTCTTGG ACAATTGCGC C 

Retrieve as FASTA  
DNA
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.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGCCCGCTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTA
CTTATCGAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTGCAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAG
TTTGGGCATCAG
GTGCGCCGGGCGGAGCGGGGCGGGGCGGGGGCGGACGTGCAGTAGTGGCTGGGGGCGCCGGCGGTGTGCTGGTGGGTGCCGTCGGCTCCATGCGCGGAGAGTCTGGCT
ACTCTCTCGTTTCCTTTCTGTTGCTCGTAGCTGCTGAAATTCCTCTCCGCCCTTGGGATTGCGCATGGAGGGCAAAATCCCGGTGACTCATAGAAAATCTCCCTTGTTTGTGGTTAGAAC
GTTTCTCTCCTCCTCTTGACCCCGGGTTCTAGCTGCCCTTCTCTCCTGTAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGTGGTGGGTTCGAGCCC
AACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCGGGGGCGCACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCGCTTATGACCGACCCC
AAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTTGCCTGGAACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGCTTCCAGACCATTGAC
ATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCCAGCTGTGCCTAG

Retrieve as FASTA  
CDS
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.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGCCCGCTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTA
CTTATCGAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTGCAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAG
TTTGGGCATCAG
GAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGTGGTGGGTTCGAGCCCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCG
GGGGCGCACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCGCTTATGACCGACCCCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTT
GCCTGGAACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGCTTCCAGACCATTGACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCC
AGCTGTGCCTAG

Retrieve as FASTA