Entry information : HsPxd03 (HsCardPOX)
Entry ID 5827
Creation 2007-10-09 (Marcel Zamocky)
Last sequence changes 2007-10-09 (Marcel Zamocky)
Sequence status complete
Reviewer Christophe Dunand
Last annotation changes 2008-06-11 (Marcel Zamocky)
Peroxidase information: HsPxd03 (HsCardPOX)
Name (synonym) HsPxd03 (HsCardPOX)
Class Peroxidasin    [Orthogroup: Pxd001]
Taxonomy Eukaryota Metazoa Chordata Mammalia Hominidae Homo
Organism Homo sapiens (human)    [TaxId: 9606 ]
Cellular localisation N/D
Tissue type Heart
Inducer N/D
Repressor N/D
Best BLASTp hits
Perox score E-value HsPxd03
start..stop
S start..stop
HsPxd02 3040 0 1..1463 1..1463
PtroPxd01 3009 0 1..1463 1..1463
MmulPxd01 2683 0 1..1463 1..1413
CjaPxd02 2663 0 1..1463 1..1456
Literature and cross-references HsPxd03 (HsCardPOX)
Literature [1] Sum A, Peterfi Z, and Geiszt M "Identification of a novel peroxidase in heart"(unpublished since December 2006)
[2] Zamocky M, Jakopitsch C, Furtmüller PG, Dunand C, and Obinger C "The peroxidase-cyclooxygenase superfamily: reconstructed evolution of critical enzymes of the innate immune system" (2008) Proteins 72:589-605
[3] Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.;
"DNA sequence and analysis of human chromosome 8." (2006)
Nature 439:331-335

Protein ref. GenBank:   AAX70929.1 UniProtKB:   A1KZ92
DNA ref. UniGene:   .Hs.444882
mRNA ref. GenBank:   AY877349
Protein sequence: HsPxd03 (HsCardPOX)
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   1463 (1440)
PWM (Da):   %s   163339.07 (160693.7)  
PI (pH):   %s   7.34 (7.35) Peptide Signal:   %s   cut: 24 range:24-1463
Sequence
Send to BLAST
Send to Peroxiscan
.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2
MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ QTTVLDLRFN RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL LYLYLYKNEI HALDKQTFKG  LISLEHLVYS FHQLEMLQPE TFGDLLRLER LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN ALVCDCDLMW LGELLQGFAQ HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP  QDVEVPSGNT VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE CMATGHPHPL  ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA NNSHGTVQAA ANIIVQAPPQ FTVTPKDQVV LEEHAVEWLC EADGNPPPVI VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ  HDQGQYECQA VSSLGVKKVS VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP IITWNKEGVQ ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI  QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP RDPLIVEMAR AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL SLIANLSGCT ARRPLPNCSN  RCFHAKYRAH DGTCNNLQQP TWGAALTAFA RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP RLVATVWARA AAVTPDHSYT RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP  PCFPMNTRHA DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE SPCFLAGDHR  ANEHLALAAM HTLWFREHNR VATELSALNP HWEGNTVYQE ARKIVGAELQ HITYSHWLPK VLGDPGTRML RGYRGYNPNV NAGIINSFAT AAFRFGHTLI NPILYRLNAT LGEISEGHLP  FHKALFSPSR IIKEGGIDPV LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT IIQRGRDHGI PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL  MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ ASLSRVLCDN GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA DCRSRGQFRA VTQESQKKRS  AQYSYPVDKD MELSHLRSRQ QDKIYVGEDA RNVTVLAKTK FSQDFSTFAA EIQETITALR EQINKLEARL RQAGCTDVKG VPRKAEERWM KEDCTHCICE SGQVTCVVEI CPPAPCPSPE 
LVKGTCCPVC RERGMPSDSP EKR 

Retrieve as FASTA  
Remarks Complete sequence from genomic (chromo 8); Peroxidase domain located between positions 726-1273; "cardiac peroxidase" ; secreted