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Manganese catalase (pseudocatalase)

  Contact author: Christophe Dunand

  Last update: 2016-12-09 (Catherine Mathe)

Manganese catalase (PF05067, Manganese containing catalase.

Interpro: IPR007760, Catalase manganese; IPR009078, Ferritin/ribonucleotide reductase-like and IPR012347, Ferritin-related.

Description Manganse catalase is non haem containing protein. They are sometimes referred to as pseudocatalases, constitute one minor catalase group and have a relatively small subunit size (28 to 36 kDa). They use two manganese ions instead of ferric heme in their active site. MnCat are able to catalyse the following reaction.

H2O2 + MnII-MnII(2H+) MnIII-MnIII + 2 H2O
H2O2 + MnIII-MnIII MnII-MnII(2H+) + O2

The nonheme catalases are not as widespread as the other heme-containing catalases. They have been identified only in bacteria. Poorly represented in Archeaebacteria (only detected in different Pyrobaculum) and Bacteroidetes/Chlorobi (only detected in Bacteroides caccae and Bacteroides capillosus). MnCat encoding sequence is not dectected neither Chlamydiae/Verrucomicrobia nor in Deltaproteobacteria nor in Epsilonproteobacteria.
Literature Kono Y, Fridovich I. Isolation and characterization of the pseudocatalase of Lactobacillus plantarum.
J Biol Chem. 1983 May 25;258(10):6015-9. PMID: 6853475

Barynin V.V. , Whittaker M.M. , Antonyuk S.V. , Lamzin V.S. , Harrison P.M. , Artymiuk P.J. , Whittaker J.W. Crystal structure of manganese catalase from Lactobacillus plantarum. Structure 9 725-738 2001 PMID: 11587647.

Chelikani P. , Fita I. , Loewen P.C. Diversity of structures and properties among catalases. Cell. Mol. Life Sci. 61 192-208 2004. PMID: 14745498.

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