The peroxidase database
<< Back << First < Previous next > Last >>
Classes

Superoxide Dismutase family

  Contact author: Christophe Dunand

  Last update: 2018-04-16 (Christophe Dunand)

Superoxide Dismutase family: FeSOD, MnSOD and Cu/ZnSOD, SOD like and Copper chaperone for SOD

Profiles

Iron and manganese superoxide dismutases (FeSOD and MnSOD) : Pfam: PF02777, Iron/manganese superoxide dismutases, C-terminal domain and PF00081, Iron/manganese superoxide dismutases, alpha-hairpin domain Interpro: IPR019832, Manganese/iron superoxide dismutase, C-terminal and IPR001189, Manganese/iron superoxide dismutase, alpha-hairpin domain.
Copper/zinc superoxide dismutase (SODC)
: Pfam: PF00080, SODC Interpro: IPR001424, Superoxide dismutase, copper/zinc binding domain.
Nickel superoxide dismutase (NiSOD)
: Pfam: PF09055, Nickel-containing superoxide dismutase Interpro: IPR014123, Nickel-containing superoxide dismutase.

Description

Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O2.-) radical into either ordinary molecular oxygen (O2) or hydrogen peroxide (H2O2). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage.
SOD catalyzed dismutation of superoxide with the following half-reactions applicable to all the different metal-coordinated forms of SOD:

M(n+1)+-SOD + O2.- --> Mn+-SOD + O2


Mn+-SOD + O2.- + 2H+ --> M(n+1)+-SOD + H2O2

where M = Cu (n=1) ; Mn (n=2) ; Fe (n=2) ; Ni (n=2).,Zn

In all mammals, and most chordates 3 SOD have been detected: two copper and zinc SOD (SOD1 located in the cytoplasm, SOD2 in the mitochondria), and one MnSOD (SOD3 extracellular).
In plants, there are three SOD classes. FeSOD (homodimer and tetramer found in chlorplast), MnSOD (homodimer and homotetramer mainly found in mitochondrion and peroxisomes) and CuZnSOD (in the chloroplast and cytosol).
In prokaryote, iron or manganes SOD can be found together with Nickel-containing SOD.

Literature

Robinett NG, Peterson RL, Culotta VC. Eukaryotic copper-only superoxide dismutases (SODs): A new class of SOD enzymes and SOD-like protein domains. J Biol Chem. 2018 Mar 30;293(13):4636-4643. PMID 29259135

<< Back