The peroxidase database
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Glycolate Oxidases family

  Contact author: Christophe Dunand

  Last update: 2016-08-24 (Christophe Dunand)


Glycolate Oxidases family :
Pfam: PF01070, FMN-dependent dehydrogenase
Interpro: IPR013785. Aldolase_TIM.
IPR012133, Alpha-hydoxy_acid_DH_FMN.
IPR000262, FMN-dependent dehydrogenase

Description Glycolate oxidase belongs to a large group of oxidoreductases that act on alpha-hydroxy acids and which are FMN-containing flavoproteins [PUBMED:2324094, PUBMED:2271624, PUBMED:1939137]. Proteins belonging to this superfamily are structurally related and are the following:

Lactate dehydrogenase (EC), which consists of a dehydrogenase domain and a haem-binding domain called cytochrome b2 and which catalyses the conversion of lactate into pyruvate.
Glycolate oxidase (EC) ((S)-2-hydroxy-acid oxidase), a peroxisomal enzyme that catalyses the conversion of glycolate and oxygen to glyoxylate and hydrogen peroxide.
Long chain alpha-hydroxy acid oxidase from rat (EC), a peroxisomal enzyme.
Lactate 2-monooxygenase (EC) (lactate oxidase) from Mycobacterium smegmatis, which catalyses the conversion of lactate and oxygen to acetate, carbon dioxide and water.
(S)-mandelate dehydrogenase from Pseudomonas putida (gene mdlB), which catalyses the reduction of (S)-mandelate to benzoylformate.
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