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Glutathione Reductase family (GR)

  Contact author: Christophe Dunand

  Last update: 2016-11-23 (Christophe Dunand)


Glutathione Reductase Family :
Pfam: PF07992, Pyridine nucleotide-disulphide oxidoreductase (Common with MDAR family)
PF02852, Pyr_redox_dim.
Interpro: IPR023753, FAD/NAD(P)-binding domain

IPR016156, FAD/NAD-linked_Rdtase_dimer.
IPR006324, Glut-diS_reduct.
IPR004099, Pyr_nucl-diS_OxRdtase_dimer.

Description Glutathione reductase (GR) (EC also known as glutathione-disulfide reductase (GSR) Glutathione reductase catalyzes the reduction of glutathione disulfide (GSSG) to the sulfhydryl form glutathione (GSH). They function as dimeric disulfide oxidoreductase and utilize an FAD prosthetic group and NADPH.
The GR are conserved between all kingdoms. In bacteria, yeasts, and animals, one glutathione reductase gene is found; however, in plant genomes, two GR genes are encoded. Drosophila and Trypanosomes do not have any GR at all

GR are defined thank to a small NADH binding domain within a larger FAD binding domain..
GR sequences are closely related to dihydrolipoamide dehydrogenase
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