Entry information : HsPGHS02 (PGHS-2 / COX-2 / PTGS2)
Entry ID 3321
Creation 2006-07-19 (Christophe Dunand)
Last sequence changes 2006-07-19 (Christophe Dunand)
Sequence status complete
Reviewer Filippo Passardi
Last annotation changes 2010-12-03 (Myriam Duval (Scipio))
Peroxidase information: HsPGHS02 (PGHS-2 / COX-2 / PTGS2)
Name (synonym) HsPGHS02 (PGHS-2 / COX-2 / PTGS2)
Class H synthase    [Orthogroup: PGHS001]
Taxonomy Eukaryota Metazoa Chordata Mammalia Hominidae Homo
Organism Homo sapiens (human)    [TaxId: 9606 ]
Cellular localisation Apoplastic
Tissue type N/D
Inducer N/D
Repressor N/D
Best BLASTp hits
Perox score E-value HsPGHS02
start..stop
S start..stop
PtroPGHS02 1264 0 1..604 137..740
CfaPGHS02 1163 0 1..604 1..604
OcuPGHS02 1139 0 15..604 15..604
SscPGHS02 1135 0 12..604 12..604
Gene structure Fichierperl './assets/cgi-bin/draw_exon.pl' '3321' 'complement(join(186643485..186643894,186644381..186644528,186645030..186645316,186645599..186645845,186645965..186646048,186646781..186646962,186647393..186647536,186648190..186648333,186648454..186648570,186649371..186649422))' Exons
ExonStart..EndSize ExonStart..EndSize ExonStart..EndSize ExonStart..EndSize
N° 1 186649371..186649422 50 N° 2 186648454..186648570 115 N° 3 186648190..186648333 142 N° 4 186647393..186647536 142
N° 5 186646781..186646962 180 N° 6 186645965..186646048 82 N° 7 186645599..186645845 245 N° 8 186645030..186645316 285
N° 9 186644381..186644528 146 N° 10 186643485..186643894 408  
complement(join(186643485..186643894,186644381..186644528,186645030..186645316,1 86645599..186645845,186645965..186646048,186646781..186646962,186647393..1866475 36,186648190..186648333,186648454..186648570,186649371..186649422))


exon

Literature and cross-references HsPGHS02 (PGHS-2 / COX-2 / PTGS2)
Literature Jones D.A., Carlton D.P., McIntyre T.M., Zimmerman G.A., Prescott S.M. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268:9049-9054(1993).
Protein ref. UniProtKB:   P35354
DNA ref. GenBank:   NC_000001.1 (186649422..186643485)
mRNA ref. GenBank:   NM_000963.2
Cluster/Prediction ref. UniGene:   Hs.196384
Protein sequence: HsPGHS02 (PGHS-2 / COX-2 / PTGS2)
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   604 (581)
PWM (Da):   %s   68838.66 (66486.5)  
PI (pH):   %s   7.56 (7.43) Peptide Signal:   %s   cut: 24 range:24-604
Sequence
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Send to Peroxiscan
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCT
RTGFYGENCST
PEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPD
SNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGH
GVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFG
LVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLIL
GETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSIL
LEHGITQFVESFTRQIAG
VAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLM
GNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL

Retrieve as FASTA  
Remarks Complete sequence from genomic (chromo 1, 8 introns) and 164 ESTs.
DNA
Send to BLAST
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGGTGAGTACCTGGCGCCGCGCACCGGGGACTCCGGTTCCACGCACCCGGGCAGAGTTTCCGCTCTGACC
TCCTGGGTCTATCCCAGTACTCCGACTTCTCTCCGAATAGAGAAGCTACGTGACTTGGGAAAGAGCTTGGACCGCTAGAGTTCGAAAGAACTCCGTGGATATTCCAGCTTTCCCACAAGC
ACTGATCATTATGAGCCAGTTACTTAACCGATCTGAGACACTCTCACCTCCTAAATAGGGATAGATGATACTAATTTGCAGGTTGTCATTATGATAAGACAGGATCTGATCAATATATGT
GAATTGTTTATATTTGGAACCTTTTTATTGAGTGGAAGAAGTTGTTTTAAATATTCTAGTCAGTTCTTTCCTGCTCCCAGGAAAGCCCGGATTATGTTTTAAGATAAGCAAAATGTCTTA
AAAGTAAGCTGTTTTACTTTGAATTTTTCCCTAAATGTTGATTAGTGTACTAGATCCATTTTAATTTGGAAAGTGAAGTGCTACTTATTTGAACTTCTTAAAAATGCTAATTTTAACATC
TAAAGAGTTAACTAAGAAAAGCTTAGTAACATGATGTACCAAGTTGAATATGCTGTTATCCTTATTTAGAATAGAAAATTGGTATTTCTACGTTTTATCCATTCTAAGGCAGGTTAAAAA
ATTGTATTTCCATGACTACCTATATATTTCTTGAATTTATTATTGTAAAGTTGATTCATAGTCAAACAATTAAATGTTTAAATTAAGATTAAGACACTAGAGAATGATTTATTTGCTGTC
CTTTAATTGCAGCACAAATCCTTGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTATAAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAA
CTGCTCAACAC
GTAAGTTTGTCCTTTGGTTGCCTCATTAGGAGTGGGGCTGGATACAGTTATCATTGTATAGATTTGTGTCTTATAATGAGTCCCATTAATTTCTCCCTCCCTTTCTTCG
TCTTCTTGCAGCGCGGAATTTTTGACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCC
TTCCTTCGAAATGCAATTATGAGTTATGTGTTGACAT
GTAAGTACAAGTGTCTTTCTAAGGTTTTTAGCCTTCTCAAAGAAAAATATGCTTTATAATACTGTAAGCCTAATCTAAAAACA
TATTTCCAAGCTTATCAAAAAGACTTTAAGATAGCTTTTAAGTTTGCCTTCCATCTTAATCGCCAAAAATATTGACATTTAGTCCCATCCAGTTTATACAGTCTGCTCACAACTCTGTAT
ACCTCTTCTAACCTTTACTGTTTGGTCAGTTTGTGGAGGTAGCATGGTCCAGCTGTTTATTGAATGCCCATGGGCCACAGAATTGTTCTGAACATGTAGCACCCATTAAAATAAATTTGG
ATTTGGATCAGCAAGAAAATAACTTTCCATGATTCTAAAGTGGGTGCCATACTCAGCCATTCCTTTCATAGGCCTCTTGGATAGTGAGCAGATGGCTACCTGAAAAATCAATATTGCCAG
ATTATAATGTGCAGAGTATATGTATTTTATTAAAGATGTATTTCAAGTGGCCATTAGACTATAAAGTGTAGTTGTTTAAAAATAGATTTTTTTTATTTTGGAGTTACATTCAACCTCAGG
TGCCACTTTCCACATTTTACAATAAAAATAATGGTTGATTTACTTAACAAATGAGAATAAATAAAACATTTTTTTCTTTGAAAATTTCAGCCCCAGATCACATTTGATTGACAGTCCACC
AACTTACAATGCTGACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCTGTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAG
GTGA
GTAAGAAGAATCCATTAGAGATGTATTAACTATAAGACGGGCTGCATTGCTGCCAAAAAAAAAAATTGACCTTAGACTACCATTTATTTATTAACAAAAGCAGTTTTTACTTTTAGCATG
GTTATCTATGGGTATTTTTTAAAGTATGAGTCTATATAAACTATTATGTAAAAGCAAATGAGCGTCTTGGTATAATGTCTTAATATTTTCAAATTATTTCTTTAGAAATGAAATAATTCT
AATTAAAATAGATAAAATCATTCAGTAAGAAGTTGTTCCACCATATCTTAGAACTGTTGTTTATATTATGATCCTATTCACAATTGTAATTCTCATATAAATGAAGAATTCTTGGTAGAT
TGACAGTCACCATCTCCTTTCTTGAATACATAGATGGATTCTTACCTTAGCTTTCTCATTTTTCAGGTGTAAAAAGCAGCTTCCTGATTCAAATGAGATTGTGGAAAAATTGCTTCTAAG
AAGAAAGTTCATCCCTGATCCCCAGGGCTCAAACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCT
GGGCCATGGG
GTAAGATAGAGTTAATATCTTAGAGTTAGTAAAATTATACCAAATCATAGTCAAGGGCTAACATTAAAGGAGATATACAGATAGATAGATCCAAATAACTTATCCACTTT
TTTTAAAAAGAAGTCTTATCTATAAAAACCTTAAAGGAATTTTCCATTTACTTCACTGGTCTAGTAAAATTATACACACACACAGACATGCACACACATATATAAACATTCACACACATA
CATATGTACAGGTATTGTTATTTGTAATTTGACCCTTGTATTTTTTAGTTTAAAATGTTAGTACTGCAAAATGTTATGTCCTCAAAAACACATTGTACCATGATTATGCCGCTTTCAATA
TTGTAAAGTGAGGTTTTTGCCGCATTATTATTTTTTGGATTTCAATAGCATAGCTTCAAGTTATTCGTAAGAATTTTTTATAAATAATACATTTTTATACTTTTTTATAATTACCATATC
ATCATAGTGAAGTATATAATATATATGATATAAGCTCAATATAGTATATTAATTCCGTTAAACACAAAGACATATCAGTTTGTAGCTTTGGTGGATAAACAAATTAATTTAGCAATTCAT
GGCTATGAAAAATGTATATTTTATTTAAAAATTTTAAAGAAAGCTAAATGATCAAATTATTTAATGATGAATTATATGATAGACACTTTATATAAGAAAAACTTCAACAGCAACAAATTA
AAATTTTTTCATCATTTTCTAGGTGTGGACTTAAATCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATATCAGGTATGCTTCCTT
TGACTATTAAGACTTAGTTATTACCGCTTATACCCATATTTTAAAATCCCTAAAAATGTGTTCCTTAACTTTTTAACTGATGTTTATTTATTTATTTATTTTTTTAGATATAATTGATGG
AGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTGGTGCCTGGTCTGAT
GATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGATGTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTAATACTGATAG
GTAA
ACAAGAAAATGATTTATATAAAACCCTCTTCCCCAGGGAAAATTAGTGTGCTATCTTTGTTATGTTTTGAGTAAATGACAAGATGTGGTAAATGAAAACTCACACATTCTATATACATTA
AATATGTAAGCATGACTGATAAAATAGCTATCTTTTGATACTGACAAGGAAGAAAACAGAAATGAAGGAATAGCAAATTTTAAAAATTGCATTCCAGTTGCTTGAAAGCTTGTGATCAGA
TGCAATAAATGTTTTTATTATTTATTTTGTGCAAATAGGAGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAAACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTAT
CAACAGTTTATCTACAACAACTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGG
GTAAGCATTATTATTGAAAACCAAAACAAAAGA
CTAGTCAGTAACTTTAGAATTTCTGCCACGGAAATTATTTTTCTTAAACTTACTAAAAGAGTAGTTAGTTATATTGCTAGTAAAATTATTTTATTGATATAAGAAGCCTAACTTTGTTTG
AAAAGTCTAAACTTTTAGTCTAGTCTACAGTTGTCAGACAAATAGCAAATTGTACCCCTACCTTAAAAATATTTTCAAAAAGTATCTATAATCTTATAGGAATAAATATTTTAGGCTTGA
ATACTAGTGTTATTTTTGAAATGTAAAAAGGCAAATTAGTTCTAGGCTGGTGTCCCATTGAATTTTAAGCAGAGCTCCTGTTGAAATGTAGGTAAGCATCTTTCCAGCAAATAAAAATTG
TCTCCGCTGGGAGTTTCAGTTTTACCTGATTTGTACCTAAGGCAAGCTGAATACAAACAGTAAATATGCCTAAAATTCTTGTTTTACAACTAATTTTACTTTCCACAGGTGTTGCTGGTG
GTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAGAGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCCTATGAAT
CATTTGAAGAACTTACAG
GTAAGAAACAGTTTCTAAACTTCTTCGTTTTTTGTTTGTTTGTTTGTTTTTGTTGTTTTTGGTTTTCTTTTCGAGATGGAGCCGCCCTCTGTCACCCAGGCT
GGAGTGCAGTGGCGCCATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAACTTCCTGAGTAGCTGGGACTACAGGCTCACGTCGCACGCATGGATAATT
TTTTGTATTTTCAGTATAGACGGGGTTTCACCGTGTTAGCCAGGCTGGTCTCAAACTCCTGACCTAGTGATCCGCCGGCTTCGGCCTCCCGAAGTGCTGGGATTACAGGCGTGAGCCACC
GCGCCTGGCCCCTAAACTTCTTAAAAGAATCAGGGGTCAAATGGAAACAGAGAAGTTGGCAGCAAATTGAGCAAAAGAATCAAACTGTTTTTTATTTTGTGAAGTTTGACATTGGTTGTA
TCTCTGTCTTCATCGCCTTCACAGGAGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCC
AGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGT
GGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGCTGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAA
TGCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

Retrieve as FASTA  
CDS
Send to BLAST
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCTTGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACAC
CGGAATTTTTGACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGTTATGTGTTGACAT
CCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCTGTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAG
GTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCAAACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGG
GTGGACTTAAATCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAG
ATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGATGTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAG
GAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGG
GTTGCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACTTACAG
GAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAATGCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG

Retrieve as FASTA