View Redoxidase 3600

Entry information : HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)

Entry ID	3600
Creation	2007-01-25 (Filippo Passardi)
Last sequence changes	2016-06-28 (Harold DuruflÃ©)
Sequence status	complete
Reviewer	Not yet reviewed
Last annotation changes	2016-06-28 (Harold DuruflÃ©)

Peroxidase information: HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)

Name (synonym)

HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)

Class

Animal glutathione peroxidase [Orthogroup: Gpx1003]

Taxonomy

Eukaryota Metazoa Chordata Mammalia Hominidae Homo

Organism

Homo sapiens (human) [TaxId: 9606 ]

Cellular localisation

Cytosolic

Tissue type

N/D

Inducer

Constitutively induced

Repressor

N/D

Best BLASTp hits

Perox	score	E-value	HsGPx01-A start..stop	S start..stop
PtroGPx01-A	409	2.37e-148	1..203	1..201
HlGPx01	407	1.13e-147	1..203	1..201
PpyGPx01	407	1.64e-147	1..203	1..201
MfGPx01	403	4.86e-146	1..203	1..201

Gene structure Fichier

Exons►

Exon	Start..End	Size	Exon	Start..End	Size	Exon	Start..End	Size	Exon	Start..End	Size
N° 1	1..252	250	N° 2	532..891	358
join(1..252,532..891)

Literature and cross-references HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)

Literature	REFERENCE 1 Sukenaga Y., Ishida K., Takeda T., Takagi K. cDNA sequence coding for human glutathione peroxidase. Nucleic Acids Res. 15:7178-7178(1987). REFERENCE 2 Ishida K., Morino T., Takagi K., Sukenaga Y. Nucleotide sequence of a human gene for glutathione peroxidase. Nucleic Acids Res. 15:10051-10051(1987). REFERENCE 3 Mullenbach G.T., Tabrizi A., Irvine B.D., Bell G.I., Hallewell R.A. Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine. Nucleic Acids Res. 15:5484-5484(1987). REFERENCE 4 Chada S., le Beau M.M., Casey L., Newburger P.E. Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics 6:268-271(1990).
Protein ref.	UniProtKB: P07203 Q6NSD4 [Fragment]
DNA ref.	GenBank: NC_000003.11 (49395711..49394824)
Cluster/Prediction ref.	Genebank: 2876 UniGene: Hs.76686

Protein sequence: HsGPx01-A (GSHPx-1 / GPx-1 / HsGPx01-A)

Sequence Properties
first value : protein
second value (mature protein)

Length (aa):	203
PWM (Da):	21853.12
PI (pH):	6.52

Sequence
Send to BLAST
Send to Peroxiscan

.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2

MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGA
GAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA

Retrieve as FASTA

Remarks

Complete sequence from 1079 ESTs, 19 cDNA and DNA (chromo 3, 1 intron).Two transcript variants HsGPx01-a and HsGPx01-b cumulated. Q6NSD4 (first 57 aa are missing: fragment or splicing variant?).

Promoter►
Send to BLAST
Send to cis Analysis

.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2

GGCGCCCCTC CTACCCCGGC TGCTTGGCAG TTGCAGTGCT GCTGTCTCGG GGGGGTTTTC ATCTATGAGG GTGTTTCCTC TAAACCTACG AGGGAGGAAC ACCTGATCTT ACAGAAAATA CCACCTCGAG ATGGGTGCTG GTCCTGTTGA TCCCAGTCTC TGCCAGACCA AGGCGAGTTT CCCCACTAAT AAAGTGCCGG GTGTCAGCAG AACTGTGTGT ATGTCCTGTG TCATTGTCAT TTGGGAATTC TTTTTCTTTT CTTTTTTTTT TTTTTTTTTT GAGACGGAGT TTTTTGCTCT ATTGCCCAGG CTGGAGTGCA GTGGCGCAAT CTAGGCTCAC TGCAAGCTCC GCCTCCCGGG TTCACGCCAT TCTCCTGCCT CAACCTCCTG AGTAGCTGGG ACTACAGGTG CCTGCCACCA CGCCCGGCTA ATTTTTTGTA TTTTTAGTAG AGACAGGGTT TCACCGTGTT AGCCAGGATG GTATCGATCT CCTGACCTCG TGATCCACCC GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTATGAGCC ACCGCACCCG GCCTGGCGAT ACTTTTTCTA ACCTCATTGT CATAGTGGTG GGAACTTAAT CCTCCTTCCC TTATCCTAGC CAAGTCTGAA CTTTCTGTCC TTTTGTCTGC AGCGTGTAGG ATCCACTCTT TCCTTTGTGG GAAGTCTGGC TCCTGGCCTG CATTTCTGCC TTCACCAGAA CATGCAAAGG GCCATCTCAA GACCCAGTTA CAACAAAGTC CTTACTTCAA AAAAGACACA AGGCAATGGT TGACTGCCTA ACTCAAATGA TAGACTTCTG ACTACTTGCT GCACGCTGAA ATGACTGTCA CAAAATAACA TGAGCCCCCA CTCACATTTG GAGTCATGGC CTCTCCAATT GTTAGGTCCA CACAATCCCA TTTTACACGG AAGCTCATGC AATGTTATAA ATTCTGTTAT CTGGCTAGAT CTTTCCATGT TGCTACCAAG TGCCTGTATC TGCTGTGACG ATGATCTTAC AAGTTTCTGC CTCATATATT CAAGAGTGAG AAAACTATAA TTTAACTGGC CCTTCTGACT ATGCCCTGCC CAACACTTAA CGTGCAATTA ATTGCACATT CAGGCCCAGG ATAAGGGCTT GTCTTTGAAG CCAGCTGCTG CTTCTCGGGC ACCACTCAGG TCCAGCCTCT CCATCTGTTG ACCCTGCTGC CAATAATCTT TAATTTTTTT TTTTTTTTTT TTTTTTTTGA GACAGTCTTG CTCTGTTGCG CAGGCTGGAG TGCAGTGGTG TAATCTCGGC TCACTGCAAG CTCCGCCTCC CGGGTTCACG CCATTCTGCC TCAGCCTCCC GAGTAGCTGG GACTACAGGC GCCCGCCACC ACGCCCGGCT AATTTTTTTC TGTTTTTTAG TAGACGGGGT TTCACCGTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC GTGATCCACC CGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCTTGAGC AGCAATAATC TTTCAAGACA GATTTGGAGC CATTTCCTAA CGCAGTGCAG GGGACTGCAG GGCCTGGGTG TAGCTTCCGC TTGTGCAAAC AGGTACCCAG AGACATGGTA GTGCTGTTCA CCCGCTGACT GTGGACCAGA GGTTCTGGAG TCCCAGCATT TGTGTTCAAA TTCGTGACTC AAGGTCCTTC TTAGTCTGAA CCAACTCTCA AGGACTTTTC CTCTTGCCCT AAGCAGTGAT CTTTGCTGCT GCTTTCCCCC TTTGTCTGCC CTTAGGTCAC TAAGGATTGT AGGGCCTTCT GGACCTGCTC TGGCTCCATC CTGAGAACTC CTGAACAGGC CCACCTCCCT CTGGTTCTCT CTGCCCCAGC CTTTGAGTCC CCCTTGGGGT GACCCAGGTA
GAACTATCAG CTTCCCCTTT GGACCTCACT CTACTTGTGT TGTTCCTTGG AACTCTCAGG AGTCTCACTC TTGCCCAGGC

Retrieve as FASTA

Terminator +►
Send to BLAST
Send to cis Analysis

.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2

ATCCAGGTTC CCTCCCAGAG GAGCCACCAG TTCTCATGGG TGGCACTCAG TCTCTCTTCT CTCCAGCTGA CTAAACTTTT TTTCTGTACC AGTTAATTTT TCCAACTACT AATAGAATAA AGGCAGTTTT CTAAACTTCC TGTATCCTGT TGTTTGTGTT GCTCTCTCCA GGGCTGGGGG TAGGAGGATG CAAGGACTTC CTGGCCTAGC TCACCCTGGA GAGGTTTGTT GAGTGCAAAG GACTAGCTTG TGCCCCACCT CCCACCCACC CAGCAGCTAA TCTGGTCCCT CCCAACAACA TGGAAATGAT TACCCTGTAC CGCATTCTGG TTCAGATTTG GGGGTAGGGT GAATGCAGCC TGAGGAGGCC AGGGAGGGAG GACTCCGGCA GCGTTTCCTT GGCCTCGGCG AGCTACTGGG CTCCACTTAA GGAGGCTGGG GCAGAGCTTC CAGGACTCTG CCCGGTTAGA AAACCCGCAC GAGGGCGGTG CCGCTTTGGA GACAGGGAGG AGGGAGACCG GAAGCCTAGA TCCCTCTGGC TGTCCCCTGC ACTGCCGGTA ACATGGCACA GGAGAGGAGG GCTGTTTGTG CACGGGCAGC TCCTGCAGCT GCTGCCGTCG CCCACCAGCC TCCTATGCCA AACCCCACAT CCTAACTCAG GAACCTCTGA GAAAAAACGG AGCCCTCGAG GGCCCCAGCC CTTGGAAGGG TAACCTGGAC CGCTGCCGCC TGGTTGCCTG GGCCAGACCA GACATGCCTG CTGCTCCTTC CGGCTTAGGA GGAGCACGCG TCCCGCTCGG GCGCACTCTC CAGCCTTTTC CTGGCTGAGG AGGGGCCGAG CCCTCCGGGT AGGGCGGGGG CCGGATGAGG CGGGACCCTC AGGCCCGGAA AACTGCCTGT GCCACGTGAC CCGCCGCCGG CCAGTTAAAA GGAGGCGCCT GCTGGCCTCC CCTTACAGTG
CTTGTTCGGG GCGCTCCGCT GGCTTCTTGG ACAATTGCGC C

Retrieve as FASTA

DNA ►
Send to BLAST

.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2

ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGCCCGCTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTA
CTTATCGAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTGCAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAG
TTTGGGCATCAGAGGTGCGCCGGGCGGAGCGGGGCGGGGCGGGGGCGGACGTGCAGTAGTGGCTGGGGGCGCCGGCGGTGTGCTGGTGGGTGCCGTCGGCTCCATGCGCGGAGAGTCTGG
CTACTCTCTCGTTTCCTTTCTGTTGCTCGTAGCTGCTGAAATTCCTCTCCGCCCTTGGGATTGCGCATGGAGGGCAAAATCCCGGTGACTCATAGAAAATCTCCCTTGTTTGTGGTTAGA
ACGTTTCTCTCCTCCTCTTGACCCCGGGTTCTAGCTGCCCTTCTCTCCTGTAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGTGGTGGGTTCGAGC
CCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCGGGGGCGCACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCGCTTATGACCGACC
CCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTTGCCTGGAACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGCTTCCAGACCATTG
ACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCCAGCTGTGCCTAG

Retrieve as FASTA

CDS►
Send to BLAST

.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2

Retrieve as FASTA