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Entry information : MtuCP01_CNFD04032
Entry ID 3607
Creation 2006-08-23 (Filippo Passardi)
Last sequence changes 2006-08-23 (Filippo Passardi)
Sequence status complete
Reviewer Christophe Dunand
Last annotation changes 2006-08-23 (Christophe Dunand)
Peroxidase information: MtuCP01_CNFD04032
Name MtuCP01_CNFD04032
Class Catalase peroxidase    [Orthogroup: CP001]
Taxonomy Bacteria Actinobacteria Actinobacteria (class) Mycobacteriaceae Mycobacterium
Organism Mycobacterium tuberculosis    [TaxId: 1773 ]
Cellular localisation N/D
Tissue type N/D
Inducer N/D
Repressor N/D
Best BLASTp hits
Perox score E-value MtuCP01_CNFD04032
start..stop		 S start..stop
MtuCP01_F16 1072 0 1..520 1..520
MtuCP01_Rm09 1072 0 1..520 1..520
MtuCP01_H37rv 1072 0 1..520 1..520
MtuCP01_H37rv 45 0.0000586 102..343 472..704
MtuCP01_An05 1072 0 1..520 1..520
Literature and cross-references MtuCP01_CNFD04032
Literature Zhang,M., Yue,J., Yang,Y.P., Zhang,H.M., Lei,J.Q., Jin,R.L.,
Zhang,X.L. and Wang,H.H.

Detection of Mutations Associated with Isoniazid Resistance in
Mycobacterium tuberculosis Isolates from China

J. Clin. Microbiol. 43 (11), 5477-5482 (2005)
DNA sequence http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=nucleotide&cmd=search&term=DQ056359&doptcmdl=GenBank
Protein ref. UniProtKB:   Q4TUW4
DNA ref. GenBank:   66737292
Protein sequence: MtuCP01_CNFD04032
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   551 (297)
PWM (Da):   %s   60127.96 (32236.1)  
PI (pH):   %s   6.66 (7.72) Peptide Signal:   %s   cut: 25 range:25-321
Sequence
Send to BLAST
Send to Peroxiscan
*.........1 .........2 .........3 .........4 .........5 .........6 .........7 .........8 .........9 .........0 .........1 .........2
MPEQHPPITE TTTGAASNGC PVVGHMKYPV EGGGNQDWWP NRLNLKVLHQ NPAVADPMGA AFDYAAEVAT IDVDALTRDI EEVMTTSQPW WPADYGHYGP LFIRMAWHAA GTYRIHDGRG  GAGGGMQRFA PLNSWPDNAS LDKARRLLWP VKKKYGKKLS WADLIVFAGN CALESMGFKT FGFGFGRVDQ WEPDEVYWGK EATWLGDERY SGKRDLENPL AAVQMGLIYV NPEGPNGNPD  PMAAAVDIRE TFRRMAMNDV ETAALIVGGH TFGKTHGAGP ADLVGPEPEA APLEQMGLGW KSSYGTGTGK DAITSGIEVV WTNTPTKWDN SFLEILYGYE WELTKSPAGA WQYTAKDGAG  AGTIPDPFGG PGRSPTMLAT DLSLRVDPIY ERITRRWLEH PEELADEFAK AWYKLIHRDM GPVARYLGPL VPKQTLLWQD PVPAVSHDLV GEAEIASLKS QIRASGLTVS QLVSTAWAAA 
SSFRGSDKRG GANGGRIRLQ PQVGWEVNDP DGDLRKVIRT WKRSRSHSTP RRRGTSKCPS PTSSCSVAVP P 

Retrieve as FASTA  
Remarks Complete sequence from genomic. A cytidine is probably lacking between "KVIRT" and LEEIQES" (DNA ttcgcacctgga <--> ttcgcacCctgga), thus provoking a frameshift that truncates the peroxidase. Either it is a sequencing error, or there is truly a nucleotide loss. Around the site "KVIRT", we have already seen insertions (but no losses) (MtuCP01_CNFD04045 and MtuCP01_C18). If an extra cytidine is added, then we obtain the sequence MtuCP01_H37rv.