Entry information : HsNOx01 (Nox-1 / NOH1 / NOX1 / MOX1)
Entry ID 5410
Creation 2007-06-14 (Christophe Dunand)
Last sequence changes 2010-12-03 (Myriam Duval (Scipio))
Sequence status complete
Reviewer Catherine Mathe
Last annotation changes 2015-12-10 (Catherine Mathe)
Peroxidase information: HsNOx01 (Nox-1 / NOH1 / NOX1 / MOX1)
Name (synonym) HsNOx01 (Nox-1 / NOH1 / NOX1 / MOX1)
Class Ancestral NADPH oxidase    [Orthogroup: NOx001]
Taxonomy Eukaryota Metazoa Chordata Mammalia Hominidae Homo
Organism Homo sapiens (human)    [TaxId: 9606 ]
Cellular localisation N/D
Tissue types Brain
Mammary gland
Inducer N/D
Repressor N/D
Best BLASTp hits
Perox score E-value HsNOx01
start..stop
S start..stop
MmulNOx01 1070 0 1..564 1..564
CfaNOx01 999 0 1..564 1..564
RnoNOx01 957 0 1..564 1..563
MmNOx01 955 0 1..564 1..563
Gene structure Fichierperl './assets/cgi-bin/draw_exon.pl' '5410' 'complement(join(100098941..100099067,100103619..100103743,100104269..100104415,100104761..100104923,100105140..100105375,100106222..100106314,100117160..100117292,100117381..100117562,100117658..100117809,100118148..100118232,100118474..100118584,100125708..100125803,100129084..100129128))' Exons
ExonStart..EndSize ExonStart..EndSize ExonStart..EndSize ExonStart..EndSize
N° 1 100129084..100129128 43 N° 2 100125708..100125803 94 N° 3 100118474..100118584 109 N° 4 100118148..100118232 83
N° 5 100117658..100117809 150 N° 6 100117381..100117562 180 N° 7 100117160..100117292 131 N° 8 100106222..100106314 91
N° 9 100105140..100105375 234 N° 10 100104761..100104923 161 N° 11 100104269..100104415 145 N° 12 100103619..100103743 123
N° 13 100098941..100099067 125  
complement(join(100098941..100099067,100103619..100103743,100104269..100104415,1 00104761..100104923,100105140..100105375,100106222..100106314,100117160..1001172 92,100117381..100117562,100117658..100117809,100118148..100118232,100118474..100 118584,100125708..100125803,100129084..100129128))


exon

Literature and cross-references HsNOx01 (Nox-1 / NOH1 / NOX1 / MOX1)
Literature Suh Y.-A., Arnold R.S., Lassegue B., Shi J., Xu X., Sorescu D., Chung A.B., Griendling K.K., Lambeth J.D. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401:79-82(1999).
Protein ref. UniProtKB:   Q9Y5S8
DNA ref. GenBank:   NC_000023.1 (100129128..100098941)
Cluster/Prediction ref. UniGene:   Hs.592227
Protein sequence: HsNOx01 (Nox-1 / NOH1 / NOX1 / MOX1)
Sequence Properties
first value : protein
second value (mature protein)
Length (aa):   %s   564 (302)
PWM (Da):   %s   64681.93 (32263.1) Transmb domain:   %s   o5-27i47-69o104-123i168-190o205-227i397-419o
PI (pH):   %s   8.59 (6.88) Peptide Signal:   %s   cut: 25 range:25-326
Sequence
Send to BLAST
Send to Peroxiscan
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKI
LG
STLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGG
SWLNPIQSRN
TVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPSWKWIL
APVILYICERILRFYRSQQKVVITK
VVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQ
YEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTK
IYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFS
TIATSHP
KSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF

Retrieve as FASTA  
Remarks Complete sequence from genomic (chromo X, 12 introns), 11 mRNA and 80 ESTs.
DNA
Send to BLAST
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATGGGAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTAAGTGATGTTTGACTTCCTATTAATTAGGAAGGATTAAGGAGAAATCATGTTTTTTAATATTTGTAAAGCAAT
TTGAAAGAGAAAGATGATTCCATGCCGATTATTGGGCTCATCAAGACCAGTTAGTTAAAAAATACAACTGTGGGTCAGATGAGAGGACAGAGGCAAATAACATGCAATTGTTCATGTTGT
CAAATCACAAGTATTTGGAATTTCAATCTGTTTTCATTTTCTGTCATCTCCCTTTCTCTTCCATCTCACTTCTAACTACTACCATGAGTGCTGATTTCTCTCTATCTTTCCTATACTGGT
CCCATCAAGATTTCAAAAAGTCACTGAATGTTTGAGATGAAAGTGATCTTAGAGATCATCTGGCCCAGTACTGACCACTAGAAATATAGCAAACCACATAATGTAATTCCTAAATTTTCT
AATACCTACACCGAAAAGGTAAAAATAAACAGGTGAAGTTAATATTTAACAATATAATTCATTTAACCCAACATATCAACAAATCCTTTCAGTATGTATTCAATATTGAAAATATTAAGA
AGCTAATTTACATATTTTTATTTTTACTGAGTCTTTCAAATCTGATGTGTATATATACCCACAGCACATCTCAGTGAGGACTAGCCACATTTCAAGTGCTCAGCAGCCCCATGTGGGTAG
TGGCTGTGGCATTGCATAGTGCAGATGTAAACCAACTTATTGATTGTACAAAGGAAAATAAGACCTAGATGTCACACAATGAATTGACTGAATTGGCATCACTCGAACCCAGCTCCCCAA
TGACGTTCAGGCCAGAACCCCTTTATCACCCTTTGTATGCACAATCCCTTTCTCCTAACACTCTAACACCTCTCTCCACTCTCATTCTTCCATTTCTGAGCCACAGTTGAGCCTGGGGCT
CCCTGTGTCCTTTCTCACTTTCCTAGATCTTCATTCATTACTCTTTCTCTTTTCTCCTGTTTTGCTTTTGGGTCCCACAGGCAAAACAGAAGAGAGAAGGTGTGATGCTTCTTTTTATTC
CTGTCTACCCCCCCGCCCCCCGACCAGGTGCTCCAGGGAAAAATATGTGGAGTTTCCCTGGAGGGTTGTTTGTTTTACATTTAACAAAAGTGCTTATTTTGTCAGGTTATCCCATGACAT
ATTTTAAATGCTCAATGCCTTATATTGAGTTCCTTTTGCACTATAATGGAAAGAACACTAGTTTAGGAGAAAGGGAACCTGGCAAGTACTTTGAATTCTGCTACTAACTGGGTGATCTCG
ATCAAATTATTTATCCTCTCTAGACTTCAGGTCCTGTGGGTGTGTAGGTGGGGGGAATTGGGCAGGGGAGGGGAGCAGGGGATTAATAAAGTGACTAGATTAGATACAAATATAAGGGTG
TTTCTAGCTCTAAAATCCACATTTACCTGCATTTTTTCCCCCTCTCTTATTTTTTGCTGGGAGAGTTTACCAGCTATGATGGTGACTCACATTTAACTCTCTAGCTTTGAATTTTCATCC
CCCACCAAACCAGCTGGCAAGCTTAGACTTCTCATTATCTCTGACATATACTCCTATGCACTGATTTTTAAATAAAAAATAAATTACTTAAAAATAGTTTTATTCCTCCTTCCTCCCAGG
TCTTGTAGTTTACCTTCTTTGACGTTCATAGTGGAGGAAATGACAGCTAAGATGGGGAATGGAATGCCTTACTCCTAGATATCACTGTATTTCATCATTTGCCTTGCCTACAATTGATGA
TGGGCTGACACAGTTATTTGCCCCTGTGTCTCTTTGCGATCCAGAAATATTTCTGCTCCCTCTAAATAAACTTCTCTCCTCTGTCTTCCAAATTCTTGAGGTGTCTGTGACTGTTGACTT
TCTTTTCTTTCAAAGACGTTTCTCTGGAAGACACTCAGCTCTGGAAAAGGGTAACTGAGCAAAGGAGGCAGGAAGAAATTGATTGGTAAAGCAGGTTCGGTGGTGACACAACTCTGTAGC
TAGCACTTATTGATCTCTTACTAAGCCCCAAGCATTGCATTAATCACTTTACACGCATTATCTGACGTAAGCCTCATAGCATTACTATAAAGTAGGTCCTGTTATTATCCTCATTTTGCA
GGTGAAGAAATTGAGGTTTAGAAAATTTAAATCATATGTCTGTCTGAGATTATAGAGCTATTAATTGGTGATGCTACAACTTGACTCCAATATCACACTTTAAATCACTATATTATAGTA
CTAAAGGTGTGTGAGTGGTCTAGATCTAGGGAGTCTGAATAGGCCATGTCCTAGGCTAAAGGCCCTTTGCCTGTTGTGCTGAGATGGTTCTGACTCATACTGTGGGGCGAGGGATATATA
CTAGCGCCCTGGAGACCTGTCGAATTACAGACTAGCACCTCCACACTTGGGCTAGAGACCAGTTGGTTGGTCCTCAAGGCAATGGGCAGTGAGTTCCAAATTTCACCTTTAGCCAGTGCA
GAGACAGAACTTGGAACAGGCAAAAGCAGTCTTAAGAGCTCAAAAAAGTCCAAAGGAAAAATAGATTAATTTGAAAAAAGACTCACAATCTGAAAACAGAAAAATGTGTGTCAGGGTGTA
ATTAAAAAGGCAGGCCCATCTGGAATGGTTTAGTTCTTTTCAGTTAGGTATTGTTATAGGTGCTAAATTTGTTCTTTGTTTCTTCAGATATCCATTTATTCACTTATTGCCATCTTTTAG
GTGCAACAGTTTGAATGCTCTAGTCCAAGAAATGGCAAATGTTTCTGTAAAAATCTAGATAGTACATATTTTAGGCTTTGCAAGCCATATGGTCTCTGTCCCAACTACTCTACTCCGTCA
TTGTATCACAAAAACAGCCATAAACAATACAAAAATGAGTAGCAGTGGCTAAGTTCCAATACCACTTTATTTATGGTCACTGAAATTTGAATTTCATATAACTTTCACATGCCACAAAAT
ATTCTTCTTTCGATTTTCTCAACCATTAGCAAATTTGAAAATATAAAATATAAAAAACAATTCTGAGCTTGCAGGCTGTGGCAAAACAGGTAATGGGCCATGGGCCTCAGTTTGCTGACC
CTGCTCTAGTCTAATGCATGTCTCAAAGTGCTAACTCACTCTGAAAGCCAGTTAGATACTAGCAGGATTGCACTCATTTAAAATGAAAACAGGTAAACACAAAATAGCCAAAACGGCGAC
ACTATTGCTATCCCTATCCCTTATTTACTCCTTCCCATACTCAAATTTCACTTTATTCTTTGCATGTTTTTTTTTCTTTCTCTAGGTGTTGTTTGGTTAGGGCTGAATGTTTTCCTGTTT
GTGGATGCCTTCCTGAAATATGAGAAGGCCGACAAATACTACTACACAAGAAAAATCCTTGGG
GTGAGTATCACGGTTGTCACGGATAGAATCTCTATTGTTTTCCTTATCTCTGATTCC
AGCTTCTTTGTGACCCAATGCCCTGATATTCTCTAGGGCTAGGGTTGCCAGAAAAAGTACAGAATGCCCAACTGACTTTGAGTTTCAGATAAATGACAAATTATTTTTTTATGTAAGTAT
GCTCCAAATACTGTATGAAACACAGGTATACTAAAATATTTATTTTAAAAAGTCTGAAGTTAAAATTTAGCTTAGCATCCTGTATTTTTATTAAATAAATCTGATAACCCCATCTAGGGC
ACACTACCCAGACCCAATAAAGGAAACATGCAATAAAGAAAACTATTAGGCAGTTGTTTTCAAACTGGTTTCCAGAAACTCAGGTGTTCCTACAGGGTATGAGGGGAAGGCTAACTGGGC
AGTGCTCCTGCTCCTGCTCCTGCCCCTATTTCTTTTTTTTTTTTTTTTACAAGGAGGAACTGGTACCATTCTTCTGAAACTATTTCAATCAATAGAAAAAGAGGGAATCCTCCCTAACTC
ATTTTATGAGGCCAGCATCATTCTGATACCAAAGCCTGGCAGAGACACAACCAAAAAAGAGAATTTTAGACCAATATCCTTGATGAACATTGATGCAAAAATCCTCAATAAAATACTGGC
AAACCGAATCCAGCAGCACATCAAAAAGCTTATCCACCATGATCAAGTGGGCTTCATCCCTGGGATGCAAGGCTGGTTCAATATACACAAATCAATAAATGTAATCCAGCATATAAACAG
AGCCAAAGACAAAAACCACATGATTATCTCAATAGATGCAGAAAAGGCCTTTGACAAAATTCAACAACCTTTCATGCTAAAAACTCTCAATAAATTAGGTATTGATGGGACATATTTCAA
AATAATAAGAGCTATCTATGACAAACCCACAGCCAATATCATACTGAATGGGCAAAAACTGGAAGCATTCCCTTTGAAAACTGGCACAAGACAGGGATGCCCTCTCTCACCGCTCCTATT
CAACATAGTGTTGGAAGTTCTGGCCAGGGCAATTAGGCAGGAGAAGGAAATAAAGGGTATTCAATTAGGAAAAGAGGAAGTCAAATTGTCCCTGTTTGCAGATGACATGATTGTATATCT
AGAAAACCCCATCGTCTCAGCCCAAAATCTCCTTAAGCTAATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAGAAATCACAAGCATTCTTATACACCAACAACAGACA
AACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAACTTACAAGGGATGTGAAGGACCTCTTCAAGGAGAACTACAAACCGCT
GCTCAAGGAAATAAAAGAGGATACAAACAAATGGAAGAACATTCCATACTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTACAGATTCAATGCCAT
CCCCATCAAGCTACCAATGCCTTTCTTCACAGAATTGGAAAAAACTACTTCAAAGTTCATATGGAACCAAAAAAGAGCCCGCATCGCCAAGTCAATCCTAAGCCAAAAGAACAAAGCTGG
AGGCATCACACTACCTCACTTCAAACTATACTACAAGGCTACAGTAACCAAAACAGCATGGTACTGGTACCAAAACAGAGATATATATCAATGGAACAGAACAGAGCCCTCAGAAATAAT
GCCGCATATCTACAACTATCTGATCTTTGACAAACCTGAGAAAAACAAGCAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGTAGAAAGCTGCA
ACTGGATCCCTTCCTTACACCTTATACAAAAATCAATTCAAGATGGATTAATGCTCCTGCCCCTATTTCAACCAAAGCAGACTATATCTATCTATGAACACCTGCTTACAATTTTAAGAA
AGAGTTTGGTTTTTTTTTAAAAAAAAGGAAAGTAAAAAAGAAAAAACAAACACAACTTGAAAACACTGCTGTCATGGAAACATACCTCTCTATCAAATAGGAGGGATACTTAGGGGAGTC
TCATGGGTGCTACAGAATTCAAGGCCTGCAGAAAGGAGGGCTCAGGTCAAGGTTACAGAACCTGAGAAGCTTGGGGAAGTGGCAGATCAAAAACAGAAGAGGGAGGGAGGGAGTGGGTAG
GGCACAGGGGTGTGGAGGTGACCAGGAGGAAGCACGGAGTTGAGGATGGTTCTCTCACAGGCTGATGAACCCGGATGCTGCCTGGTTAGAAGAGCATATTTGACTGCTACCTCTAGTCTA
TTATGCAATAACAGATAGAGGATTTTAAATCACTTTCATCTTGACAGTGTCATTTTTTCAGTAGCTTTTGGTATCTTCCCAATGTACATGTTTAAAGACAGCTTGTCCTTTTAAAAAATG
CTTTTTTCTCTCTCCATAATCAAAGAATCCATGTTGAGATCACAACTAATTTGAACGTTCTGTTCATGGTTTATTTCACCCTGCTGTTTTCCATTTTAAATGTTCATCCTTGATCCTTCT
TTAGAAACTATAACTCCAAAGGAGGTATTAATTTGCTTTAAAAATAGCTTTTTACTAAGAGAATGATGCAATAAATGTGACTAGTTATTAACAGCTTGATTACTACATGACCAAAATGTC
AGCAGCACAAAAATAAATTATGCTGATGTCCCATGGACATTTTTTTTTCAAAATTATTTAAAAATTGTTTACATATGTAGGGGGTATAAGTGCAGGTCTCTTTCTTTCCTTCTTTCTTTT
TTCTCTTTCTTCCTTTCTTTATTCTTCCTTCCTTTTCTTTCTCTTTCTTCTCTCTCTCTTTCTTTCCTTCCTTCCTTCCTTCTTTCCTTCTCTCTTTCTCTCTCTCTTTCTTCTTTTCTT
TTCCTTCCTTCCTTCCTTCTTTCTTTCTTTGTTTTCATTCTTTTTATTTTGAGACAGGGTCTTTCTCTGTTACCCAGGCTGGCATGCAGTGGCATGATCATGGTTCACTGCAGCCTCGAC
TCTCCCAGGCTTCAGCTATCTTCCCACCTCAGCCTCCTGATTAGCTGGGACCACAGGTGTGCGCCACCAAGCCTGGCTAATTAATATGCCATAATTTATTTAAACATTCCACAGTCATTA
AAACATTTACCATCACTGCATAACTGCATAGAGCTCTCAGCCTTTTAAGAGAATAACAATTCATTGCATTGATATGCCATAATTTATTTAAACATTCCACAGGTTATTTCTTAAATTCAT
GCTCACCTTGGGAAAATACAGGGAACAATTTGATTCACTATGAAGTAGAGCAGATAAGCAGCAGAGGAAGAAGTTTAAATCCATAATTTAAAAACATTTTTTTGCCAGGCGCTGTGGCTC
ACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCACGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGC
GAGCGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGCAGAAGAATGGCGTGAACCCAGAAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCCA
GACTCTGTCTCAAAAATAAATACATAAATAAATAAATACTTTTTTTTTGTAGACATGAGGTCTCCGTGTTGCTCAGGCTAGTCTCAAAACTCCTGGGCTCAAGTAATATTCCCACCTCGG
CCTCCCAAAGGCCGGGTATTACAGGTGTGAGCGACCATGCCCAGTCACAAGTGTAGGTTTCTTACATGCATATATTGCATAGTGATGAAGTCTGGGTTTTTAGTTACCTATCACCTGAAT
AGTGAACATTGTACCCAGTGGGTCATTTTTCAACCCTCACTCCCCTCCCACCCTCCCACATTTTGTAGTCTCCAATATCCATTATTCCACTCTGTAGGACATTTCATTTTTTAAATCCCT
ATTTTAAAACCTTAATTATCAATAATGCTGCTTCCAATGAGATCAAAGCACATATTAGTTTGGTGCAAAAATTATTGCTATTAAAACTGTTTGCAAAAACCGCAATTACTTTTGCACCAA
GCGAATAGAAGTGTATAAGTAAAATGTGAAAATCTCCCTCCCATCCTACTCCCCAGAGATACACACACACACACACACACACACACACACACAGGGACACACACACTGACATAAGCTCAC
AAATGTATCAGACACGCAGGTTTTGTTTTTGAGGTGGGTACTATCGTTTATTCACTTTTTCATTTTCATATAGTAAAATTTGCTGTTTTTTGGTATACAGTTCTATGAGTTTGGGTAAAC
ACATATAATAAGACACACAGCTTTTTGTTTTAACCAAAAAAGGGATCACTTTGTAGATATTGGCTGGAAATTGCTTATGTTAATATATCTCAGATATCTTTCTTTCTTTTTTTTTTTTTT
GAGATGGAGTCTCACTCTGTCGCCCAGCCTGGAGTGCAGTGGCGCAATCTCTGCTCACTGCAACCTCCACCTCCTGGGATCAAGCGATTTTCCTGCCTCAGTCTCCCAAGTAGCAGGGGT
TACATGTGCGAACTTTCATGGCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGATCTCAAACTCCTGACCTCAAGTGATCCACCCGCTTTGGTCT
CCCAAAGTGCTAGGATTACAGGCGTAAGCCACTGCTCCCAGCCTCAGATATCTTTCCATGTGAGTGCCTAACCAGTGGTGTGCTGAAACCAGCTCATACCAGGTTGCAATGCCAGTTGCG
TGCATCTCTTCCCAACTCTGCATTCAGTGGTGTTCAATGACATCAAGTTAGTGTCTTGAAATCTGGCATGGTGGGAGTATTTACATCATCAAAATTGGCAAATGCTGGAAATCAGGAATC
CCCTTCCTCCCAAAAAGCTAGTCATTAAAACATTTACCATCACTGCATCACTGCATAGAGCTCTCAGCCTTTTAAGAGAATAACAATTCATTGCATTGATATGCCATAATTTATTGAAAC
ATTCCACAGGTTATTTCTTAAATTCATGCTCTGCTCACCTTGGGAAAATACAGATAACAATTTGATTCGCTATGAAGTAGAGCAGATAAGCAGCAGAGGAAGAAGTTTAAATCCATAGTC
AATTATGCATTAATGACAGCAGGAGTTCAATTATAACACCAGTGAGTGGAGATCTAGAGAAATGAACATACATTGGCATATTTAAATGTGCTGCAACGAGGAAAAAATGTTTTCTCTAAA
AAGAATTCATCCTATACAGATAGCCACCACAGAATATGGAACTGTGAAATTATAGTCCTATATTTTCAATTCACTTGCCAATTTTAGCTTTAAGAAATCTCTGTGATTCAAATAAGCAAG
TAGTGGGAACCAATGTGGAAATGCAGGATCTCTGAGATGAGCAGAGGAAATTTACTCAGAAGTGGAACAGGCTGTCTGTACCAAAAACAGTCAGGGTGTGAGTCAGCAGAGGGAGAAAAC
ACAGGTCATGTGGAAAAGCCAGAAATGGAAAACAGTAGGGCAGCTTTTGTTCACCACATTGCCTGACATTCTTAGCCATTATAGATACTAGGCAGATCTTGTCCTGGCTTATTAAACTAA
CATCACATGTTCCTGGGTTTACGATATAAGGAAAAATCAATTTTGTGCTTCATAGATAATTACAAAAAGGCCAAGAAATTGTTAACCTTAACCCATACCCCTCCTTTTAGAAAGTCTTTG
ACAGGCACACAATGTAAGGCTGGCCAGTCAGCAGAAGTGCAACAAAAATTGCCTGGCTGCTGCTGTCAGCTCCTCTGCTACAACATTGTCACACTCCATAGCAGTCCCAAGTTCATGAAG
TAGACTCAGAGACCGGTTGTACAGAGTTGAGGAGAGAAGTCAGATTTAGCTGCCATGGAGTTAAGCATATTCTGTCCAGCTTATACCTAGTAAGGCCTGTTTTTTGGGGCTAAATGCTTC
TTTGAAGCATTGATTCCTTGTCTCCTTTGCTAGCAGCTTCTACTGCTGGATCAGGTTGTTCTTGATTTATGCTGCCTGGCCACCCAAGGAAATCAGCTTAAAATTTTGCTCCTCTGAAGT
TCTCCCTTCTCAAATATCTACCTGTTTAAAAATTTTGCTCCAAGAGGTTTGCTAGTCTTGACTAAATTTATTCAATTTTTAAAGACATCTTAAATAGAATTGGTTAAAAATTTTAAGTGT
TTTTATTATACAACTCTTATGTGCTTATAACTGCAATATTAGAAAATACAGAAAAGAATAAAATACCATCTGTAATTGTACCTCTAAGTATGAGCTTTATTTAAAATGCAAATAAAGGTA
TATATGATCCTTGGCCAGGCATGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCAAAGCAGGCAGATCTCTTGAGCTCAGGAGTTCCAGACCAGCCTGGGCAACATGGCAAAAC
CCTGTCTCTACCAAAAATACAAAAATTGGCTGGGTATGGTGGTGCACGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATGGCTTGAGCCCAGGAGGCAGAGGATGCAGTGA
GCCGATATCTCGCCACTGCACTCCAGCCTGGGCAATAGTGCCAGACCTTGTCTCAAAAAGAAAAATCTATATCTATATCTATATCTATATCTATATCTGATCCTTAGGACTCTTTTACAA
GTGACAAATAACAAAATTATAATAAAGAGTATTAAGTAAAATGTTACAGCCATAGAATGTTTTGCTAACATGTAATCATTAAATCCTATTCTCTTTCATGTTAATAAATGTAGTCAAACA
TTTCCAAACTACTGTCATGGGAATTTCTCAACTCAATATTAAATTCAGTATGTTTTATGTATTTTGCAAACAGAGCCTGGCCTGATGGTGTTAGCTACTGAGAGAGAGGAGAGGCAGCTG
TAGCCCTGTTCATTTGCAGGCCTCAGATGAGTGGGCTGGGTCAGTTGCTCACGTGCTAGATGGTGAAATGAAGCAGCTGATGGTCTCTTTTTCTCCTCTGCTGTAGTCTCAACATTGGCC
TGTGCCCGAGCGTCTGCTCTCTGCTTGAATTTTAACAGCACGCTGATCCTGCTTCCTGTGTGTCGCAATCTGCTGTCCTTCCTGAGGGGCACCTGCTCA
GTGAGTCCCAACCACTCCTAA
GTCAACTTTCACATTAAAGAAGGAGACCCCAGACTCCTCAGTAGGACAGTCCAACACCATGCTCCTAGGAATGGAAGCTAGAAGTCTCCTTTGGTAGCTAAGGGGGTGGGTTAGTGCGGG
TGAGTATTGGCATGCTATATGCAAGACATATTGGTTATGGGTTAGTGAATTTAATAAAGCTGGCTGGCGACATCTGACCATGATCATTCTACATTTGTAGTTTTTTGCAGCCGCACACTG
AGAAAGCAATTGGATCACAACCTCACCTTCCACAAGCTGGTGGCCTATATGATCTGCCTACATACAG
GTAACTCAGGCAATCCATGAATCTGCAGACTCCAGGGCATTCAGAATCTTGCT
TCATTCATCCATCCATATGCACATTCAAAAAATATTTATCGAGCACTGGGCACTATTTGTCAGGCACTGTTCTTGGCCTGTTTTCATGGAGCTTAAGTTCTATTCCTTTGGGAACAGAGT
AAATATAAAAAAGATCTCTCCGCAATCGAGGGTTTATTGGGCACCTTCTGTGCACTCAGCATTCTGCTAAGCACTATAATGTAGGATTCTTCTAGTCTAGTGGGGCACACCTGCCATGAT
GTTGCTGAGATGCCTCTTAACATTTCTTTTCATCTTTCCATTTAGCTCTATTCACATCATTGCACACCTGTTTAACTTTGACTGCTATAGCAGAAGCCGACAGGCCACAGATGGCTCCCT
TGCCTCCATTCTCTCCAGCCTATCTCATGATGAGAAAAAGGGGGGTTCTTGGCTAAATCCCATCCAGTCCCGAAACACG
GTGAGTTGACTTTCTAGCAAAGCATCTGAGATCTGGTCATG
AGCAGGAAGTGCACAGGTGGACATTGTGTCAGGCTGACATTTCTCCTTTCACAGACACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACTGGAGTGATCATGACAATAGCCT
TGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGGAGGAGTTATTTTGAAGTCTTCTGGTATACTCACCACCTTTTTATCTTCTATATCCTTGGCTTAGGGATTCACGGCATTGG
GT
AAGATCCTCGAACCCTCATTCTCATGCCCCAGCCCCTGACCTTGCATAATTCTTTGTCCCAAACCATCCTTCTTTGTCTATTTCAGTGTGGAATTGTCCGGGGTCAAACAGAGGAGAGCA
TGAATGAGAGTCATCCTCGCAAGTGTGCAGAGTCTTTTGAGATGTGGGATGATCGTGACTCCCACTGTAGGCGCCCTAAGTTTGAAGGGCATCCCCCTGAG
GTAAGAGCCCTACGGGCAA
GGACAGACTCTTGTTAGGAGCTGTTACTGTTATTATTCTTATTATTACTCTTATTGTTATTATCATCATTATTATTAGTTCAGTCCTGTGCTGGGTCTTATGAAGGATATCTATGGGGTT
CCTACCTTTAAGAAACTTCCAGTATCACTGGCAACAGGCAATTACAAGGGGATCTTGAAGAGAAAAAACTAATAGTTCTTGCATGTTGTGAGACCCTCTGCAAAGGTAATAATGATAGCC
CACATTATTAATTGTGTTTATCATCTGCCAGCCTTGCTGCATAATATGGATTATTTCATTTATATATAGCAATAGCCTATGAGATATTACTTCTTTTTTGTCTAAATTTTGAAACAAAAG
GACAGGATTCCAAGAGATTAAGTAAACTGACAAGCTCTTACAGTAAGTAGTGGAGCTTGAATACAAACCCAGGCCTTTTGGATTCCAAAGGTTTGAACTCTTGACCACTATACTGTCCCA
AAGCTCAGCCGTGATATTCCAGTCAAATTCTGGGGGGAAATAAAGCATTCTTGAAGTGGGCTTTCTTTGGTGTTCTAAGAATATGCTTGGAAATTTTTGTTAGATACTGGGTGATTATGA
AACTGTGTTCTAGGGAACTCAAGGTGTGCCCCAGGGTAATTCTTGCGGATATTATTATTTACCTTTGCTTGCTCACAAAATAGGTTATATTGAGGAGTAAATGGAAGGGGAAGGTTGATT
TGTGGTGCCTCAGAGTATTCTGAGAATGATTAAGGTCTTTAAATCAGATTCAGGATTAAGAGCAATAGCTTAGTTCTCATCTGGAACAGGAAAAATATATAAAACAAAAAGTCTTCTAAA
GTTGGCATTTTAATTCAGCAGGAAAAGGATAAATGAATAATTTTTAGCACAATAAGATCATCATCTGGGAAAAAAGCTATATCTTCATTTCACGCCTTGCACTAAAATATGAATCGAGGA
TACATGAAGCAAAAAAACCATAAAAGCACCTTAAGACCACGTGGGAAGTTTTTTTCTAATACTGAAGTGGAGGAACATGTTTCTAAATAAGATAAACCACCCTGAAGCCATAAAAGAAGA
GATAATTTTGCATGGCAAAAGAAATCCCCATCGGGCCGGGCACGGTGGCTCACACCTGTAATCCCAGCAATTTGGGAGGCTGAGGTGGGTGGATTGCTTGAGCCCAGGAGTTTGAGACCA
GCCTGGGCAACATGGCAAAACCCCATCTCTACAAAAAATACAAAAATTAGTTGGGCATGGTGGTGTGGAGGGTGAGGTGAAAGGATTACTTGAGCCTGGGAGGCTGAGGCTGCAGTGAGC
TGTAATCATGCCACTGCACTCCAGCCTGGGTGACAGTGAGATCCTGTGTCAAAATAAACAAACAAATAAACAAAAATTCCCATTGTAAATAAAGATAGACAAAAAATTACCAAGTAGGAA
AAGTATTTACAACTCACAGGGCATGGACTAATTTTCTAATATATAAATAACTCCTAGAAATCAATAAGAAAAAGCCTAATAACATGATAAAAAGAGAAACAGAAGATGTGAACAGAATAA
TCTCAGAAATGGAGATATATCCTTATCTTAAATATATGAAATGATGCTTAATGTTATTCATAATGGAAAAAAATGCCAAATAAAACTACAAGAATCTGTTAACCTAACAGATTAGCAAAG
ATTAAAAAACCTGCTAATGTATGGTGCTGGCAAGTGTGGAAAAATGCTCTTATGCATTGCTGGTGAGAGTGTAAACCTATACAACTGCTTGTAGAGAGTGATTTGGCAGTAGCAATTAAG
GTTTAAAACTCGACTTCCAATTTATTCCACAAATATACTTAAATATGTGTTAAATTACATGCATTAAGTTATTCATTACAGCATTGTTGAATAGAAAAAAAGACTGGAAACAAGTGTCCA
TCAGTGGGGAACTAGTTACATTTTGGGACTTTCATGCAGTGGAATAGTCTGCAACCAGTAAAACGAAAGAGACAGTACCATAGACACTAATAGGGACCAGTCTCTAAGATGTTAAATGCA
AAAGGCAGGGCAGTGTGTAGAGTCTCCTATCATTTGCATTGAAAAGATCATTTAAATGCATGTTCTCCAGAAGAATTCACAAAATAATAACATTACCTCTGGGGATCTGGAGGGGCAGGA
GGATTTGCTTTTTACTATTGTACTGTTGTACTTTCAGATTTTGTACCATATACATATATTACCTATTTAGAAAGTAATTTTCTAATAAGATAGATAGAATGCTAGCTACACAAATAAAGA
ATAGACCACTAGCTACACTAATAAAGAAAAAAGAGAGACAATCCAAAAAACACAATCAGAAATGGCAAAGAGGACATTATGACTGACCGCACAGAAATTAAAAAAAAAAAAACCCTCAGA
GACTACTATGAACATCTCTATGCACACAAACTAAAAAAAAAAACAACCTAGAAGAAATGGATAAATTCCTGGACACATACAACCTCGCAAGACCAGACCACGAAGAAATTTAATCCCTGA
GCAGACCAATATTGAGTTCCAAAACTGAATCAGTAATAAAAAAGCCTACAACTAAAAAATGCCCAGGACCAGATAGATTCACAGCCAAATTCTTCCAGATGTACAAAGAAGATCTGGTAC
CATTCCTACTGAAACTATTGCAAAAAAATTGAGGAGGAGGGTCTCCTTCCTAACTCACTCTATGAGGCCAGCATCATCCTGATACCAAAACGTGGCAGAGATACAACGAAAAAAGAAAAC
TTCAGGCCAATATCCCTGATGATCATTCATTGATGAAAAAATCCTCGACAAAATACTGGCAAACTGAATCCAGCAGCACATCAAAAAGCTAATCCACCACGATCAAGTAGGCTTTATCCC
TGGGATGCAAGTTTGGTTCAACATATGCAAATCAATAAATGTGATTCATCACATAAAGAGAACTAAAGACAAAAATCATATGATCATCTCAGTAGATACACAAAAGGCTTTCAATAAAAT
TCAACATTCCTTCATATGAAAAACTCTCAGCAAACTAGGCATTGCTGGAACATATTTCAAAATAACAAGAGCCATCTATGACAAACCCACAGCCAACATCATACTGAATGGGCAAAAGCT
GGAGGCATTCCCCTTGAAAACTGGAAAAAGACAAGGATGCATTCTCTTACCACTCCTATTTAACATCGTGCTGGAAGTCCTGTCCAGAGCAATCAGGCAGGAGAAAGAAATAAAAGGCAT
CCAAATAGGAAGACAAAAAGTCAAACTATCCCTGTTTGCAGACAATATGATTCTATACCTAGAAAACCCCATAGTCTATGTCCAAAAGCTCCTAGATCTGATAAACAGCTTCAGCAAAGT
TTCAGGATACAAAATCAATATACAAAAATCAGTAGCATTGCTATACCCCAACAACACCCAAGCTGAGAGCCAAATCAAGAATGCAATCCCATTCACAATAGCCACAAAAAAAATAAAATA
CCTAGGAATACAGCCAACTAGGGAGGTGAAAGATCTCTACAATGAGAGTTACAAAACACTGCTCAAAGAAATTAGAGATGACACAAACAAATGGAAAAACATTCCATACTAATGGATAGG
AAGAATCAATATCATTAAAATGGCCCTACTGCCCAAATCAATTTACAGATTCAACACTATTCCTACCAAACTACCAATGACATTCTTCACAGAATAAGAAAAAAAAACTATTTCAAAATT
CATATGAAACCAAAAAAGAGCCCAAATAGCCAAGGCAATCCTAAGCAAAAAGAACAAAGCTGGAGGCATCATGTTACCCAACTTCAAACTATACAAGGCTACAGCAACCAAAACAGCATA
GTACTGGTATAAAAACAGACACACAGACTGATGGAACAGAATAGAGAGCCCAGAAATAATGTTGCATATCCATGACCATGTGATCTTTAACAAAGTCAACAAAAATAAGCAATGGGGAAA
GGACTCTGTTCAATAGGTGGTGCTGGGATAACCGGCTAGCCATATGAAGAAGATTGAAACTGGACTCTTTCCTTACACCATATACAAAAACCAACTCAAAATGGATTAAAGACTTAAATG
TAAAACCCCAAACTATAAACACCGTAGAAGACAACCACCCTGGAAGACAACCTAGGCAATACCATTCAGGACATAGGCCCTGGCAAAGATTTCATGATGAAGATACCAAAAGCAAATGCA
ACAAAAATAAAAATTGATGAATGGGATCTAATTAAACTAAAGAGCTTCTGCACAGCAAAAGCAACTACCAAGAGAGTAAACAAACAACCTACAGAATGGGAGAAAATATTTGCAAACTAC
ACATCCGACAAAGGTCTAATATCTAGCATCTATAAGGAACCTAAACAAATTAACAACAACAACAAAAAAACACAAATTATCCCATAACAAAGTGTGCAAAGTCTCAAAAAAAAAAAAAAA
GTGGGCAAAGGACATAAAGAAACACTTTTCAAAAGAAGACACACACGCAGCCAACAAGCATATGAAAAAATGCTCAACATCGCCGATCATTAGAGAAATGCAAATCCAAACCACAATGAC
ACACCATCTCACGCCAGTCAGAATGGCTATTATTAAAAAGTCAAAAAATAACAGATGTTGGTGAGGTTGCAAGGAAAAGGGAGCACTTATACAGTGCTGGTGGAAATGTAAATTAGTTCA
GCCATTGTGGAAAGCAGTGTGGTAATTCCTCAAAGAATTGAAAACAGATTACCGTTTGACCTAGCAATCCCATTACTGAGTATATACCCAAAGGAATATAAATCATTCTATGACAAAGAC
ACATGCACTTGTGTGTTCATTGCAGCACTATTCAAAACTGCAGACATGGAATCCACCTAAATGCCCATCAATGGTAGACTGGATAAAGAAAATGTGGTACATATATACCATGGAATACTA
CGCAGCCATAAAAAATAACAAGATCATGTCCTTTGCAGCAAGATGGATGGAGCTGGAGGCCATTATCCTAAGCAAACTAATGTAGAAACAGAAAACCAAATATCACATGTTCTCATTTAT
AAGTGATAGCTAAACATTGAGTACATATGCACACAAAGAAGGGAATAACACACTGGGGCCTACTTGAGAATGGAGAAAGGGTGGAGAGAGAGGATCAAAAAACTATCTAATGGGTAGTAG
GCTTATTACCTAGGTGATGAAATAATCTGTACACCAAACCCCTGTGACATGTAGTTTACCTGCAAACTGCACATGTACCTCTGAACCTAAAATAGAAGTTAAAAAAAAAAGTAATTTTGG
GTGGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGAGGATTGCTTGAGCTCAAGAGTTCGAGACCAATCTGAGCAACATAGGAAGACCTTGTCTCTACAG
AATATTAAAAAATTAGCCGGGCATGGTGGTGCACGACTCTGGTTCCAGCTACATGGGAGGCTGAGATGGGAGGATCACTTGAGCCCAGGAGATTGAGGCTGCAGTGAGCTGTGATGGCAC
CACCGCACTCCAGCCTGGTTGACAGAGAAAGACCCCATCTCAAAAAAAAAAAGTAATTTTGGAAGGACATACCTGGGATATGTTAATAGCACATTTCATTTCTAAAGTCAGAGGAAATTA
TAAGATCATAACCAGGGATCTGTATTAGCGGACTAGTAGACAAGAGGACCTTAAAGATAGGGAGCTATTGCCTTTCCGCCCGTGTACGCCACTGAAGAAGCATCGTTAAAGTCTCTCTTC
TCCCTTCCATCTTGTCTAAGTCAGAGTCTCCTAAAGAGCTCAAACAGCTGAGGAAGCTCTTCATTGGAGATTTGAGCTTTGAAACAACTGACGAGAGCCTGAGGAGCCATTATGAGTGAT
GGGGAATGCTCACAGACTGTGTGGTAATGAGAGATCCAAACACCAAGCGCTCCAGGGGCTGTGGGTTTGTCACATACGCCACTGTGGAGGAGGTGGATGCAGCCACGAACGCAAGGCCAC
ACAAGGTGGATGGAAAAGTTGTGGAACCAAAGAGAACTGTCTCAAGAGAAGATTCTCAAAGACCAGGTGCCCACTTAACTGTGAAAAAGATATTTGTTGGTGGCATTAAAGAAGACACGG
AAGAACATCACCTAAGAGATTACTTTGAACAGTTTGGAAAAATGGAAGTGATTGAAATCATGACTGAGGCAGTGGCAAGAAAAGGGGCTTTGCCTTTGTAACTTTTGACGACCATGACTC
CGTGGATAAGATTGTCATTCCGAAATACCATACTGTGAATGGCCACAACTGTGAAGTTAGGAAAGCCCTGTCAAAGCAAGAGATGGCTAGTGCTTCATCCAGCCAAAGAGGTCGAAGTGG
TCGTGGAGGTGGTTTTGGTGGGAATGAAAACTTTGGTTGTGGAGGAAACTTCAGTGGTCATGGTGGCTTTGGTGGCAGCCATGATGGTGGTGGATATGGTGGCAGTGGGGATGGCTATAA
TGGATTTGGTAATGATGGTGGTTATCCAGGAGGCGGCCCTGGTTACTCTGGAGGAAGCAGAGGCTATGGAAGTGGTGGACAGGGTTGTGGAAATCAGGACAGTGGCTATGGCAGGAGTGG
CAGCTATGACAGCTGTAACAAGGGAGGCAGAGGCGGCTTTGGCAGTGGTAGTGGAAGCAATTTTGGAGGTGGTGGAAGCTACAATGATTTTGGCAATTACAACAATCAGTATTCAAATTT
TGGACCCATGAAGGGAGGAAACTTTGGGGCAGACGCTCTGGCCCCTAGGGTGATGGAGGCCAATACTTTGCCAAACCACCAAACCACAGTGGCTATGGCGGTTCCAGTAGCAGCAGTAGC
TATGGCAGTGGCAGAAGATGTTAATTGGGAATCAAAGCTTAGCAGGAGAGGAGAGCCAGAGAAGTGACAGAGAAGCTACAGGTTACAACAGATTCATGAACTCAGCCAAACACAGTGGTG
GCAGGGCCTAGCTGCCACAAAGAAGACATGTTTTATACAAATACTCATGTTTATGGGCAAAAAAGTCAAGGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTCTA
TGGAAAGTGTAAAGCATTCCAACAAAGGGTTTTAATGTAGATTTTTTTTGCACCCATGCAAAAAATTGCTATATGTGATAGTCTGATCATGACACTGAATAAATGTCTTTTTTTTTTAAT
GTGCTGTGTAAAGTTAGTCTACACTGAAGCCATCTTGGTAAATTTCCCCAACAGTGTGAAGTTAGCATTCCTTCAGGGTGATGCCAGGTTCTATTTGGAATTTATATACAACCTGCTTGG
GTGGAGAAGCCATTGTCTTCAGAAACCTTGGTGTAATTGAATTGATAGTTACTGTTGTGACCTGAAGTTCACCATTAAAAGGGACTACCCAAGCAAAATCATGGAATTATTGGTTATAAA
AATAATTGTTGGCACATCCTATGCAATATATCTACGTTGAATAATGGTACCAGATAAAATTATAGATGGGAATGAAGCTTGTGTATCATCCATTATCATGTGTAATCAATAAACAATTTA
ATTCTCTTGAAAAAAAAGATAGGGAGCTATTTAAAGATTATTAGGAAAGCTTACTAGCTAAGATGGTTAATACCTTGTCTTATCTTGCACATCAGCTTCTGTCTTTTTCTCATCTATTAC
CTGAGTTAAGTTATAGTTGGTCTATTTGGTATCCTTAAAACTTAGGGGTTGCTTTGGTTGGTCGTGTAATACTCTAAGAGAGAGAATACCAGTTTTGCCACCTGAATGTATTGCTTTGTT
TCTTCCATAAACATTTAAAAAATACTCTCTCCATATTCACCCCATTTAAAAATTAGAAAAATAATATACATTTATTGTAGAAAGTTTGGAAAATACAAAAAATACTAGAAGTAAATAAAA
AATTTCATAGAGTTCTACCACCTAGAGGAAATAATGTTTTTCCTTGATTGATATAATGGATGCTTTCCTTTGAAACATTTTTTTTTGTTTTGAGACAGTCTCCCTCTGTTACTCAGGCTA
GAGTGCAGTGGTGTGATCTTGTCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCGCGCACCACCACGCCCTGCTAATT
TTTGTATATTTAGTAGAGACGGGGTTTTGCCACGTTGACCAGACTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTGGCTTCCCAAAGTGTTGGGATTACAGGCGTGAGCCAC
CGCACCCGGCCTTGAAACATTTGTTTTAAAATAGTTGGCCAGGAGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCATTCGAGGCCAGCAGTTCCAGA
CCAGCCTGGCCAGCATGGTGAATCTCCATCTCTACTGAAAATGCAAAAATTCGCCAGGTGTGGTGGTGCATGCCTGTAGTTTTAGCTAATTGGGAGGCTGAGGCAGGTGGATCATTCGAG
GCCAGCAGTTCCAGACCAGCCTGGCCAGCATGGTGAATCCCCATCTCTACTGAAAATGCAAAAATTCGCCAGGTGTGGTGGTGCATGCCTGTAGTTTTAGCTACTTGGGAGGCTGAAGCA
GGAGAGTTGCTTGAACCCGGGAGGCGGGGGTTGCAGTGAGCCGAGACTGTGTGACTGCACGGAGTGAGACTCTGTCAAAAAAAAAAAAGAAAGAAAGAAAGGAAGGACGCAAGGAAGAAA
GCAAGGAAGGAAGGAAGGAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAA
AGAAAGAAAGGAAGGAAGGAAGGAAGGAAAGAAAGAAAAAGAAAGAAAGAGAAAGAGAAGGAAAATATGTGTATGGTATATATACCATTTTAATCATTTCTTAAAGTAAACATTGTGGCC
ATTACTTTACTCGTGCATAATACTTTTTCACACCTTAATTATTTATCTTCATTTCCCAGAAGTGAAGTTCCAGGGTAAAAGAGAAGGAATGCTTTTGAGGCTATTGAGACATACTGCTCA
ACTGCTCTCTGGGAAGATGTTGCCAATTTGCATTTTCACCCCTGTGAAATGCATGTTCAATTTGCATGCCCACGTGAACACTCCCATTTCCCTGAATCCCAGTTAATGCTGGGCATTATT
AATTAAAATTGTTTTTCAATTTGAGAGACTAAAATGGTATCTTGTTTTAATATTTATTACTCTGACTATTTCTGAGGCCAATATTTTTTTCACATTGTTATTATCCATTTCTTAAATATG
TTTTTCCTCAAATTGAGCTGGGGAATTTTCTTCAAATAAGAAATAGCACTGAATTGCATAATGTTCACTCTGTTTGATTTGTCCCATCTCTGCCTCTTCCTTCCCTAGAGATACTCAAGG
AAGTTATTTGCTTGCACCAGCTTAAGAAACCTCACTTCACACAGTCCCAATGTATCACACTTGAGCAACTGTGCAAGAAAGGACATAATTTAGTATTGCTAGGAAGTATATTTTTAGTAG
TTCCTGTGCAGGTAGAAGCAAACTGCTGCTTTGCAAAGATCTCAGGGATAGAAAAGCTGCTTTATTTATTTATTTATTTTATTTATTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTG
GAATGCAGTGGCGCGACCTGGGCTCACTGCGACCTCCTGGGTTCGAGTGATTCTCCTTCCTCAGTCTCCCGAGTGTCTGGGATTACAGGCACCCACCACCACACTCGGCTAATTTTTGTA
TTTTTAGCAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCTCAAGTGATCCACCCGCCTTGGCTTCCCAAGGTGCTGGGATTACAGGCGTGAGCCACTGCGCC
TGGCCAAAAAGCTGCCTTTAAAAAAAATGTAGACAAGGTAAAAAAGATATTACTATGTTAAATGTTTAAGCACTTGAGAAAGGAGGTGATGGATAAGTACTGAGTTTTATGTACCAGTAG
CATCAGTCACATACTTTCCCTTTTTTGTGTTTGTTTTGTTTTTAATCATCTGCCTCTATTTCACATCTACTTTCTCTGTTGGTTTTTTAGATTGGACAAGCTGTCCTCGAAGACAGTCTT
AGATTCTTAAAATTAAATCTTATTTTATTTTTTTGGAGACAGTGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTGCCTCCTGGGTTCA
AGCGATTCTTATGCCTCAGCATCCCATGTGGCTGGAATTACAAGCATGCACCACCACGCGCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCGCTATGTTGCCCAGGCTAGGTC
TCCAACTCCTGAGATCAGGCAGTCTGCCCGCCTCGGCCTCCTAAAGTGCTAGGATGAGCCACTGTGCCAGGCCTTAAAATTAAATTTTATATGTAATTTAAGAATAAGAATATTTACCAT
GTGTTCCATTTCTGTGCTTTTCTCCTGCTTCTTGGTCAGACTTGTAAATTTTCAGGAAATGGTCTGTTTTATGAATAACAGATTAGCAAACGAAACCATTGTCCTTTATTTTTTCTATTT
CCATCTTCCAGATTTGGTGAAATTAGTAGCTTAAAAATGATACACATTGGAGAACTCAGTAAAGAATGAAGGATGAACTGCTACACAAATAAGTCCTAAACAAGAAATTAGTGTGTAATC
TCATTCTTAACCCTGTCTCTGTGCAGTCTCTTGGAAGTGGATCCTTGCACCGGTCATTCTTTATATCTGTGAAAGGATCCTCCGGTTTTACCGCTCCCAGCAGAAGGTTGTGATTACCAA
G
GTAAAGAATATGCACTTTCCTCTTGCTGTGATAAGAGTTATCTTCTACCGGACTACAGAACTAAATTTTTATGTTGTCACCCTGAAAGAGGAACTTGGAAACTGGGCACAGTGGGTGGT
AGTCCCAGCACTTTGGGAGGCCAAGGAGGGCAGATCTGTTGAGGTCAGGAGTTCGAGACCAGCCCGGCCAACATGGCGAAACCCCATCTCTAATAAAAAAAAAAAAATTAGCTGAGCGTG
GTGGTGCCCACCTGTAATTCCAGCTACTTGGGAGGCTGAGGCGGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTTGAAATAGCGCCACTGCACTCCAGCCTGGGTGACAG
AGAGAGGCTCTGTCTCAAAAAAAAAAGAAGAAGAACTTGGGTTTGGCATACCTCAGTTCCTCCAGCACTGGACAGAACTGGGAAAGAGGGGCTTGGCCGAAATCATCAGGATGAGTCTAT
ATCAGAGGTTGCAAACAGGCAGCCTGGGCCAGAGCTAGTTCACAGCTATATTTTGTTTGGTGCACACAATGTTTGTTTATAAAGTTGAATTGGTTGCCAACATTTAAAAATCTGGATGGA
AGCTTTCGTTTGATTTTTTAAAAGCTATTTCTTGCTTCTCTTGAAGAATCAGGAAACCTGATAACACTGTCATGGTTCCATATCGCAACCACTGTCTGGAGCTAAGTAGCTGCTGCCCTC
TTTAGAGAGGACTTGTGTTTGTAGTTCACCACTGTCACCAGCCCTCCAGCTTCACTCATTTGCTTTATCTGCCTGTCCCTGTCGTCATTAGAGTTTGCTTTCTTTGGTCTATGTGCTTCA
TTCACAGGTGTTGTTATGCACCCATCCAAAGTTTTGGAATTGCAGATGAACAAGCGTGGCTTCAGCATGGAAGTGGGGCAGTATATCTTTGTTAATTGCCCCTCAATCTCTCTCCTGGAA
TGGCATCCTTTTACTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCATTCATATCCGAGCAGCAGGGGACTGGACAGAAAATCTCATAAGGGCTTTCGAACAACAATATTCACCAATT
CCCAG
GTAGGTCCTTGAGACCAGGAGAGTCCCAGACCAGGATGCAGACTGGCAGAAAAGAGAAAGCAATTCTTCGTTGAATCTTAAGTTTGGTACAATAGAATAGGATTATAATAAATAT
GCAGAAGTCAGCCATGAGAACAACTATATTTCTGGGAGGATGTTTGAGGTTGGAGGTGGAGGGGAGTCTTCAGTTGCCCGTTATCTTCTGTCTTCTGCCAGGAGATTGAAGTGGATGGTC
CCTTTGGCACAGCCAGTGAGGATGTTTTCCAGTATGAAGTGGCTGTGCTGGTTGGAGCAGGAATTGGGGTCACCCCCTTTGCTTCTATCTTGAAATCCATCTGGTACAAATTCCAGTGTG
CAGACCACAACCTCAAAACAAAAAAG
GTATAATCCCGTATATCACTTTTCTTCTGGCCTGAGTCTGACAAGTCTATTGCCTTCTTGGGCTAAGCTCTTTACAATTGATAAGGGAGCAACC
TATCCCTGGAGTTATGAGAATAAGTGATCACTTCTCTTGGCCAGGACATCCACTTCTACAGATTTATCATAAGAACAGGGTCTTCTTTTCAATTTGGAGTTTAAGATCACCCTGACCAAA
GATGTTGGAAGGCTCGTTCCTAAGGAAAATTGTCAGAACTCTGAACATTCCTGCTGCCTAAAGTTTGCGGCTCTATAAATGTGACTTTTAAGGTCACCTAATAAGGCTATGTTCTCTCTT
GCTGATTTCAGATATCTATTTCTACTGGATCTGCAGGGAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGAACAGGAGATGGAGGAATTAGGCAAAGTGGGTTTTCT
AAACTACCGTCTCTTCCTCACCGGATGGGACAGCAATATT
GTGAGTCCAAATAACACACTAATTCCCCTACTAAACATAAGACGAATGTCAGACAAAGGATAGTGCATATGGATTAGAAG
TTATTTCTTATGATTTCCTACCTGCCCTCACACTCACACACAAGTTTAAAAGTGGTGGAAAGAAGAGGCAGCTATCAGGACTTGGTTTTTCTTTTCTTTCTTTCTTCTTTTTTTTTTCTT
TTTGAGACAGAGTTTCACTCTTGTTGCACAGGCTGGAGTGCAATGGTGCGATCTTGGCTCACCACAACCTCTGCCTCCTGGGTTTAAGCAATTCTCCTGCCTTAGCCTCCCGAGTAACTG
GGATTACAGGCATGCGCCACCATGCCCAGCTAATTTTGAATTTTTAGTAGAGATGGGGGTCTCACCATGTTGGTCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTCGG
CCTCCCAAAGTATTGGGATTACAGGCGTGAGCCACGCACCCAGCCTAGGACTTGGTTTTTCTAACTTTTATTCCTCTGAATCCAGGTGTTGGTCATGCAGCATTAAACTTTGACAAGGCC
ACTGACATCGTGACAGGTCTGAAACAGAAAACCTCCTTTGGGAGACCAATGTGGGACAATGAGTTTTCTACAATAGCTACCTCCCACCCCAA
GTAAGTATATTTTCCTCTAGTAAGATGA
GTTTACAGGGGCCGTGCGTGGTGGCTTACTGCCTGTAATCTCAGCACTTTGGGAGGCCGAAGTGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGTCTGGCCAACTTGGCAAAACCC
CGTCACTACTAAAAATACAAAAATTAGCTAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAATGAG
CTGAGATAGCGCCATTGCACTCCAGCCTGGGCAACAAGAGAGAAACTCTGTCTCAAAAGAAAAAAAAAAAGATGAGTGCGGAGTTAGGATTTAGGAAAGGTATTACAACATGTTGAACAC
TCTTAAGAAAAGATCTCTGGGGCAGAAATCTTTTGTGCCATTCTTAGATTCTTGGTGAAGACCGAGGAAATTTCATCTGGGGTTTTAGAAAAATAGGGTCATGATCTTGAAAATGATGAA
AAGAGGTTTTTTTGCCCCAGCAAACTCCATTCAAACAGTGAGGCAAGTGGACCCACTTCTGATCTATACTACCAAACAAACTAGAGAACTGGAGCAATTCAAATGCATTTTTGCGGGGAG
GGGACTCAATAATCTCTACTTAAAGTAACAAAGGTATTATCTAGTTTACTGGCCACCTGAGCTCAATCTTTCTGGAGGGTTTTGAGACATGTTACAGCACAAAAAATCCTGGTGCTATGA
AATCAGCCATTCCAATGGGAAGGAGATGAAGCTGAGATTCCCTGAACAAGTAGGGAGGTGATGATCAATTCAATGCTACAAATATTCTTGATTACCTTTTTTTTTTTTTTTTTTTGAGAT
GGAGTTTCGCTCTTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTCTGCTTGCTGCAATCTCCGAATCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCATGTAGCTGGGATTACA
GGTGCCCACCACCATGCCCAGCTAATTTGTTGTATTTTTAGTAGAGATGGTGTTTCACCACGTTGGTCAGGCTAATCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCCCCAA
AAGTGCTGAGATTACAGGCATGATCCACCAAGCCCCGCCTTGGTTACCTTTTATAAGCTCAGCTCTCACCATTCTAGAAGCTTTGGAGGTTGAAAGAGAAATAGGATATGGTTCTTGCCC
ACAAGGAACATACATTTGAATAAGAGATGCACACAATCACCTCAAAGCAGAATAATGCACTCCGTGAAAGAGGTTCACGGATGCTGGAGGGAAGAAAAGTCTACGGCCACATGGGGTGAT
TAGGAAAGGCTTCAGGAAGGCAGTGGCTAGAGCACTTAGTGACTTGGATTCAGATGATCCTGGGTCCTCATGCTGGTTCTCTCTTTTTTTCTCGAGACACAGTCTTGCTTTGTCACCCAG
GCTGGAGTGCAATGGTGCCATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATCCACCACCACATCCAGCT
AATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATTCACTCACCTCAGCCTCCCAAAGTGCTGGGATTACAGCATGAG
CCACCATGCCCGGCCCTTATTCTGGTTCTGACACTTTCTAGTTATGAGACCTTGAACTTCTGAACTCTCTGATCTTGATTCCTCATCTGTAAGACAAGGGTCATATTAGTGAATGCCTGC
TCTACTCACTTGCAGGGTTGTTATGACAATTAAGTGAGACAATATATGAAAAAATGCTTTGTAAATTTTAAAGCAGCATATAAGCATAAAAGATGCTAATTATCATGTTGAATGTAACTG
AAGTTTTGAGAGAGTATGAGGTTGTCAGGAGAGAGAGAGAGAGGGAGGGAGAGAGAGAGACTAGCGAGGGACAGAGTACCAAGGAATGCTGCCTAGGTTATATGGGAAGGGAAAAAGACA
AACCAGGGAAGAAATAGGAGTACACAGAGAAGTGGTGTCACAGAACCCAAGGGAGCAAATATTAGAGAAGCGTGGTCAATAGTGTTGGAAGAGTAGCAGGGTCAGGAAATGTTCATTTAG
CTTAAGCATATTTATAGACAGAACAAGGACCAGTACATAAAATAAAATAAATACATGAAAGAGGGGAGAGGACTAAGATGGCCATAATAAAAGATGGACAATAGTATTGGCAAGGAAGTG
GAGAAGTTGCAATCCTAGTACATTGCTTGTGGAAATGTGAAATGATACCACACTCGGGGAAAACTCTTTGGCAGTTCCTCAAAGTGTTAAACACAGTTTCCAGCTGGGCATGGTGGCTCG
CGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGATGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCTTGTCTCTACTAAAAATACAAAAAATTAGGCC
GGGCGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTTTACTAAACAT
ACAAAAAAAAATTAGCCGGGTGCGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAAGCTGAGGCAGGAGAGTGGCGTGAACCCAGGAGGCAGAGCTTGCAGTGAGCCAAGATCGTGCC
ACTGCGCTCCAGCCTGGGCGACAGCGAGATTCCATTAAAAAAAAAAAAGGTGAAAAGAATTAGCTGGGCATGGTGGCGGGCACCTGTAATCCCAGCTACTAGGGAGGCTGAGGCAGGAGA
ATCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGACCCCAGATCATACCATTGTACTCCAGCCCGGGTGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAACACATAGTTT
CCATATGACCCAGCAATCCCACTCCTTGTTATACACCCAAGAGAAATGAAAATATATGTCTACACAAAAACTTGTACATGATGTACATAGCAGCATTACTCATAATAGCCCCGAAGTGAA
AACAAGCCAAGCATCCATCAATAGATGAATGGATGAAGCAAATGTAGTATATTCACATACTGGAATATTATTTAGCTATTAAAAAAAAAACAAAGTACTGAATCATGCTACAACATGGAC
AAATCTTGAAAACATCATGCTGAAAAACACCAGACACCAAAGGCCATGTATTGTATGATTCCACTTATGTGAAACATTCAGGATAGGCATACCCACAGAGACAGAAAGTAAAGTGATTGT
CTTGGGTAGGACAGGGTAGTTGGGAGGAAATGAGGACTGCTAATGTGGATGGGGTTTCTTTGCGGATGATGAAAATGTTCTGGAATTAGATAGTGGTGATGGTTGCATAACTTTGTGGCT
GTGCTAAAAAGCACAAATTGCACACTTCAAAGGGGCGAATTTTATGGTATAGAAACTATACCATAATTATATTTTTAAAAAAGAGGGGGAGAGAAAGGTATGAGAGAAGGAAGAAGACGG
TGAGACCCAGAGCATAGTTGGAAAGATTAGCTTTGGCAAGAAAGAACACTACCTCTCCACTAGGAGAAATTTTGAGGTAGGGATAAGCTCACAGTGGATGGGTTTAATGGGAGCTAATAC
ATATGTACTTGCTATGTGCCAGGCATTTTTCTAATTTATTTACATGTTCTTATTTAATCCTTAAAACAACCCTATGTGGTAAGTACTATTTTTATCCCCATTTTACAGGTGGGAAAGCTG
AAACAGAGAGAGGTTAAGAAATTTTCCCTTGTCGGACATTGTGGCTCACGCCTGTAATCCCAGCACTTAGGGAGGCTGAGGCAGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCT
GGCCAACATGGTGAAACCCCATCTCTAATAAAAATACAAAATTTAGCTGGGCATGCTGGTGCGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATTGCTTGAACCTGGGA
GGTGGAGGTTGCAGTGAACCGAGATTGTGCCACTGCACTCCAGCTGGGGGACAGAGCAAGACTCCATCTCAAAAAAAGAAAAGAAAAAAGAAAAAAAGAAATGTGCCCAAAGTCCCACAG
GTGGGATAAATGTCAGAGCTGAGATTTGAGCCCAGACAACCCAGACAGACTGGCTGCACAGTCTGGCACTTAGCCACTGCACTGTCTTATGTCTGTCATCTGTGTTCTCAAAACAGGGAA
GGCTGAGTGCTGAGAGTGTTAAGGGCTGAGAGCATATTTGGGGTTTGTGCGCAGAAAAGGTTAAAAAACTACCATGAAGAACGTGGGAGTAAACAACCGAATTTTTATTCAAGGTTCTTG
GAAGTAGTAGAGGCCTAACAGAGGCAGTTTCTCCATTCTGTCATTGCTGCATTCTAGCCCTTACTATTGTTCTGTTCCTACAGGTGTCTGTAGTGGGAGTTTTCTTATGTGGCCCTCGGA
CTTTGGCAAAGAGCCTGCGCAAATGCTGTCACCGATATTCCAGTCTGGATCCTAGAAAGGTTCAATTCTACTTCAACAAAGAAAATTTTTGA

Retrieve as FASTA  
CDS
Send to BLAST
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0.........1.........2
ATGGGAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTTGTTTGGTTAGGGCTGAATGTTTTCCTGTTTGTGGATGCCTTCCTGAAATATGAGAAGGCCGACAAATACTAC
TACACAAGAAAAATCCTTGGG
TCAACATTGGCCTGTGCCCGAGCGTCTGCTCTCTGCTTGAATTTTAACAGCACGCTGATCCTGCTTCCTGTGTGTCGCAATCTGCTGTCCTTCCTGAGG
GGCACCTGCTCA
TTTTGCAGCCGCACACTGAGAAAGCAATTGGATCACAACCTCACCTTCCACAAGCTGGTGGCCTATATGATCTGCCTACATACAGCTATTCACATCATTGCACACCTG
TTTAACTTTGACTGCTATAGCAGAAGCCGACAGGCCACAGATGGCTCCCTTGCCTCCATTCTCTCCAGCCTATCTCATGATGAGAAAAAGGGGGGTTCTTGGCTAAATCCCATCCAGTCC
CGAAACACG
ACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACTGGAGTGATCATGACAATAGCCTTGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGGAGGAGTTAT
TTTGAAGTCTTCTGGTATACTCACCACCTTTTTATCTTCTATATCCTTGGCTTAGGGATTCACGGCATTGG
TGGAATTGTCCGGGGTCAAACAGAGGAGAGCATGAATGAGAGTCATCCT
CGCAAGTGTGCAGAGTCTTTTGAGATGTGGGATGATCGTGACTCCCACTGTAGGCGCCCTAAGTTTGAAGGGCATCCCCCTGAG
TCTTGGAAGTGGATCCTTGCACCGGTCATTCTTTAT
ATCTGTGAAAGGATCCTCCGGTTTTACCGCTCCCAGCAGAAGGTTGTGATTACCAAG
GTTGTTATGCACCCATCCAAAGTTTTGGAATTGCAGATGAACAAGCGTGGCTTCAGCATGGAA
GTGGGGCAGTATATCTTTGTTAATTGCCCCTCAATCTCTCTCCTGGAATGGCATCCTTTTACTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCATTCATATCCGAGCAGCAGGGGAC
TGGACAGAAAATCTCATAAGGGCTTTCGAACAACAATATTCACCAATTCCCAG
GATTGAAGTGGATGGTCCCTTTGGCACAGCCAGTGAGGATGTTTTCCAGTATGAAGTGGCTGTGCTG
GTTGGAGCAGGAATTGGGGTCACCCCCTTTGCTTCTATCTTGAAATCCATCTGGTACAAATTCCAGTGTGCAGACCACAACCTCAAAACAAAAAAG
ATCTATTTCTACTGGATCTGCAGG
GAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGAACAGGAGATGGAGGAATTAGGCAAAGTGGGTTTTCTAAACTACCGTCTCTTCCTCACCGGATGGGACAGCAAT
ATT
GTTGGTCATGCAGCATTAAACTTTGACAAGGCCACTGACATCGTGACAGGTCTGAAACAGAAAACCTCCTTTGGGAGACCAATGTGGGACAATGAGTTTTCTACAATAGCTACCTCC
CACCCCAA
GTCTGTAGTGGGAGTTTTCTTATGTGGCCCTCGGACTTTGGCAAAGAGCCTGCGCAAATGCTGTCACCGATATTCCAGTCTGGATCCTAGAAAGGTTCAATTCTACTTCAAC
AAAGAAAATTTTTGA

Retrieve as FASTA