Dehydroascorbate reductase family (DHAR)
Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the soluble cytosolic (cGST), mitochondrial (mGST), and membran bound microsomal (MGST). Members of the GST superfamily are extremely diverse in amino acid sequence.
Ascorbate is oxidized by Ascorbate peroxidase (APx) to monodehydroascorbate (MDA), spontanously oxidized into dehydroascorbate (DHA). MDA and DHA are reduced back to ascorbate by MDA reductase (MDHA) and ferredoxin, and DHA reductase (DHAR).
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