Monodehydroascorbate Reductase family (MDAR)

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Last update: 2021-12-02 (Bruno Savelli)

Monodehydroascorbate Reductase (MDAR)


In plant cells, the rapid regeneration of ascorbic acid (AsA) is controled by both dehydroascorbate reductase (DHAR) and monodehydroascorbate reductase (MDHAR) which are a part of the AsA-glutathione (GSH) cycle.
MDAR are defined thank to a small NADH binding domain within a larger FAD binding domain.


Monodhydroascorbate Reductase Family :
Pfam: PF07992
Pyridine nucleotide-disulphide oxidoreductase
Interpro: IPR023753
FAD/NAD(P)-binding domain


Johnston E.J., Rylott E.L., Beynon E., Lorenz A., Chechik V., Bruce N.C. Monodehydroascorbate reductase mediates TNT toxicity in plants. Science 349:1072-1075(2015). PMID:26339024.

Park AK, Kim IS, Do H, Jeon BW, Lee CW, Roh SJ, Shin SC, Park H, Kim YS, Kim YH, Yoon HS, Lee JH, Kim HW Structure and catalytic mechanism of monodehydroascorbate reductase, MDHAR, from Oryza sativa L. japonica.Sci Rep. 2016 Sep 22;6:33903. PMID:27652777